{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:33:25Z","timestamp":1792708405620,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"vor","delay-in-days":151,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:p>Chronic active Epstein\u2013Barr virus infection (CAEBV) is a syndrome that takes diverse clinical courses and is often associated with lymphoproliferative disorders of T \/ natural killer (NK)\u2010cell lineage. We describe a patient with CAEBV associated with persistent pharyngeal ulcer, and with subsequent nasal T\/NK\u2010cell lymphoma in her neck lymph nodes and nasopharynx. Immunophenotyping of lymphoid cells showed that the lineage of Epstein\u2013Barr virus (EBV)\u2010positive cells in the patient was of NK\u2010cell origin. By means of high\u2010dose recombinant interleukin\u20102, we established an EBV\u2010positive cell line of NK\u2010cell lineage from her peripheral blood. Southern blot analysis for the number of terminal repeat sequences of EBV detected three NK\u2010cell clones in the patient\u2019s lymph node. One of these clones was identical to the established cell line but was not observed in the pharyngeal ulcer, while the other two clones were present in the pharyngeal ulcer. These results suggest that the patient had expansion of the three NK\u2010cell clones, one of which had proliferative capacity <jats:italic>in vitro<\/jats:italic> and was involved in the formation of the lymphoma. Moreover, the results suggest that the proliferative capacity of EBV\u2010positive cells can be variable even in a single patient, and this variability may explain the clinical diversity in CAEBV.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2001.01276.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:15:26Z","timestamp":1047489326000},"page":"778-785","source":"Crossref","is-referenced-by-count":18,"title":["Presence of natural killer\u2010cell clones with variable proliferative capacity in chronic active Epstein\u2013Barr virus 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