{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:08:33Z","timestamp":1759730913461},"reference-count":47,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2002,7,11]],"date-time":"2002-07-11T00:00:00Z","timestamp":1026345600000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>Human T\u2010cell leukemia virus type 1 (HTLV\u20101) infection is prevalent in native Americans living in the Andes. Some of their malignant lymphomas (ML) show a peculiar histology suggestive of adult T\u2010cell leukemia\/lymphoma (ATLL). To determine whether ML resembling ATLL are indeed ATLL, re\u2010analysis of 34 cases occurring in Jujuy, a province of Argentina, was conducted, concentrating on immunological phenotype, integration of HTLV\u20101 proviral DNA, expression of HTLV\u20101 p40Tax and p27Rex, and infection of Epstein\u2013Barr virus (EBV). The ML were 22 cases of mature peripheral T\u2010cell and natural killer (NK)\u2010cell neoplasm (mT\/NKN), 11 B\u2010cell malignant neoplasms and one Hodgkin's lymphoma. Polymerase chain reaction against the HTLV\u20101 proviral DNA, using DNA extracted from paraffin sections, indicated integration of the HTLV\u20101 proviral DNA in three cases of eight mT\/NKN. Two other cases of mT\/NKN were positive for anti\u2010HTLV\u20101 antibodies. Expression of p40Tax and p27Rex was detected in all five of these mT\/NKN cases associated with HTLV\u20101. As such, these five mT\/NKN were rediagnosed as ATLL. <jats:italic>In situ<\/jats:italic> hybridization signals for EBV\u2010encoded small nuclear early region\u20101 were detected in nine cases of mT\/NKN, of which five cases of NK\u2010cell lymphoma were found to have cytoplasmic CD3 expression, a CD56 phenotype and positivity of TIA1. According to the new World Health Organization classification, the mT\/NKN class includes five cases of ATLL and five cases of NK\u2010cell lymphomas. The five cases of ATLL were of native American extraction from an HTLV\u20101\u2010endemic area around Jujuy, north\u2010west Argentina.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2002.01356.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:18:56Z","timestamp":1047489536000},"page":"348-357","source":"Crossref","is-referenced-by-count":15,"title":["Adult T\u2010cell leukemia\/lymphoma in Jujuy, north\u2010west Argentina"],"prefix":"10.1111","volume":"52","author":[{"given":"Oscar","family":"Marin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Hasui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Remondegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moe Moe","family":"Aye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Takenouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Izumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"},{"key":"e_1_2_6_4_2","first-page":"73","volume-title":"Topics in Hematology.","author":"Takatsuki K","year":"1977"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210203"},{"key":"e_1_2_6_9_2","first-page":"217","article-title":"Positive and negative regulation of HTLV\u20101 gene expression and their roles in leukemogenesis in ATL","volume":"39","author":"Yoshida M","year":"1992","journal-title":"Monogr. 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