{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:25:31Z","timestamp":1758633931060},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2002,12,11]],"date-time":"2002-12-11T00:00:00Z","timestamp":1039564800000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>Membrane\u2010associated mucin MUC1 is expressed in various adenocarcinoma cells and active T lymphocytes. We tried to find out whether MUC1 is expressed in gastric mucosa\u2010associated lymphoid tissue (MALT) lymphoma lesion. MUC1 was not expressed in infiltrating T lymphocytes; however, MUC1 was found on the cell surface of follicular dendritic cells (FDC) of germinal centers and in the epithelial cytoplasm of lymphoepithelial lesion (LEL) of the lymphoma, which were immunohistochemically detected by monoclonal antibodies DF3 and MY.1E12. MUC1 was also expressed in the FDC of control cases (gastrectomy specimen containing reactive lymphoid follicles, <jats:italic>n<\/jats:italic>\u2003=\u200310, MUC1\/DF3, 100%; MUC1\/MY.1E12, 40%), and FDC in MALT lymphomas (<jats:italic>n<\/jats:italic>\u2003=\u200359) showed lower MUC1 expression rates (MUC1\/DF3, 32%; MUC1\/MY.1E12, 0%) than the control (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Lymphoepithelial lesion in the low\u2010grade MALT lymphomas (<jats:italic>n<\/jats:italic>\u2003=\u200323) showed a higher MUC1\/DF3 expression rate (30%) than those in the high\u2010grade MALT lymphomas (<jats:italic>n<\/jats:italic>\u2003=\u200336; 6%; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). T lymphocytes in the surface mucosa were more frequent in MALT lymphoma (91.4\u2003<jats:italic>\u00b1<\/jats:italic>\u200380.6\/unit area) than those in the control (20.0\u2003<jats:italic>\u00b1<\/jats:italic>\u200323.6) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). S100\u2010positive dendritic \u2002 cells\u2003around\u2002LEL\u2002were\u2002more\u2003frequent\u2002in\u2002the low\u2010grade\u2002 (19.0\u2003<jats:italic>\u00b1<\/jats:italic>\u20039.4\/unit\u2003area)\u2003than\u2002 in\u2002 the\u2002high\u2010grade (11.7\u2003<jats:italic>\u00b1<\/jats:italic>\u20039.7) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.005). This study demonstrated MUC1 mucin expression on FDC for the first time. Mucosa\u2010associated lymphoid tissue lymphoma, especially low\u2010grade, shows immunologically active state, where FDC MUC1 expression may be suppressed by some factors released from lymphoma cells. Further study to elucidate the pathogenetic role of MUC1 in MALT lymphoma is necessary.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2002.01411.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:18:23Z","timestamp":1047489503000},"page":"691-701","source":"Crossref","is-referenced-by-count":10,"title":["MUC1 mucin expression in follicular dendritic cells and lymphoepithelial lesions of gastric mucosa\u2010associated lymphoid tissue lymphoma"],"prefix":"10.1111","volume":"52","author":[{"given":"Chiaki","family":"Taki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Kitajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunobu","family":"Sueyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Yonezawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadao","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koro","family":"Sakoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Irimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,12,11]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Extranodal Lymphomas.","author":"Isaacson PG","year":"1994"},{"key":"e_1_2_6_3_2","first-page":"1271","article-title":"B\u2010cell monoclonality precedes the development of gastric MALT lymphoma in Helicobacter pylori\u2010associated chronic gastritis","volume":"152","author":"Nakamura S","year":"1998","journal-title":"Am. 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