{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:40:15Z","timestamp":1792147215496,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,9,5]],"date-time":"2008-09-05T00:00:00Z","timestamp":1220572800000},"content-version":"vor","delay-in-days":2105,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p>An autopsy case with a widespread mucosal carcinoma of the biliary tree was reported. A biochemical profile of the bile duct damage was noticed in a woman in her seventies during a gastric examination. Imaging procedures depicted irregular dilatations of intrahepatic bile ducts with a bead\u2010like appearance. Elevated levels of serum alkaline phosphatase and \u03b3\u2010glutamyltransferase with a negative antimitochondrial antibody persisted. The patient was diagnosed as primary sclerosing cholangitis, she was followed up for 4 years under preservative therapies, and died of anasarca and heart failure. Post\u2010mortem examination showed a diffuse mucosal carcinoma of both intrahepatic and extrahepatic biliary passages including the gallbladder with a minimal invasion and scattered foci of adenoma\u2010like area in part. There was no evidence of gallstones or pre\u2010existing sclerosing cholangitis. The striking features of the tumor were extensive papillary growth, mucus secretion and irregular dilatation of bile ducts. The tumor may bear biological and morphological homology with intraductal papillary mucinous tumor of the pancreas.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2002.01419.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:18:18Z","timestamp":1047489498000},"page":"784-788","source":"Crossref","is-referenced-by-count":7,"title":["Diffuse mucosal carcinoma of intrahepatic and extrahepatic bile ducts including gallbladder"],"prefix":"10.1111","volume":"52","author":[{"given":"Joji","family":"Haratake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,9,5]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1236","volume-title":"Diseases of the Liver","author":"Okuda K","year":"1993"},{"key":"e_1_2_6_3_2","volume-title":"Pathology of the Liver","author":"MacSween RNM","year":"2002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/27.1.18"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80275-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310104"},{"key":"e_1_2_6_7_2","first-page":"661","article-title":"Cystic dilatation as a radiographic sign of cholangiocarcinoma complicating sclerosing cholangitis","volume":"78","author":"Gluskin LE","year":"1983","journal-title":"Am. 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