{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:48:27Z","timestamp":1761918507165},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,6,17]],"date-time":"2003-06-17T00:00:00Z","timestamp":1055808000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p>We investigated the diagnostic and prognostic value of p53 expression and proliferative activity, as indicated by the Ki\u201067, in endoscopic biopsy specimens. Specimens were immunologically stained with p53 and MIB\u20101 (Ki\u201067), and the MIB\u20101\/Ki\u201067 labeling index (LI) was calculated. Classification of adenomas was based on findings of H&amp;E\u2010stained preparations into those with low\u2010 or high\u2010grade atypia. Well\u2010differentiated tubular and papillary adenocarcinomas were classified as carcinomas with low\u2010 or high\u2010grade atypia. There were significant differences among the control and adenoma patients in MIB\u20101\/Ki\u201067 LI (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). No significant difference was identified between adenomas with high grade atypia and carcinomas with low grade atypia. The p53 expression was negative in all adenomas, but it was positive in 68.2% of carcinomas. The current study demonstrated that p53 protein expression in endoscopic biopsy specimens was of preoperative diagnostic value for carcinoma of the ampulla of Vater. The p53 protein positive tumors had a relatively higher malignant potential than p53 protein negative ones. The MIB\u20101\/Ki\u201067 LI was useful in differentiating non\u2010tumorous lesions from adenomas and adenomas with low\u2010 or high\u2010grade atypia. The MIB\u20101\/Ki\u201067 LI had a prognostic value because clinicopathological factors of carcinoma of ampulla of Vater correlated with MIB\u20101\/Ki\u201067 LI.<\/jats:p>","DOI":"10.1046\/j.1440-1827.2003.01482.x","type":"journal-article","created":{"date-parts":[[2003,6,17]],"date-time":"2003-06-17T08:11:57Z","timestamp":1055837517000},"page":"361-370","source":"Crossref","is-referenced-by-count":9,"title":["Usefulness of endoscopic biopsy using immunostaining of p53 and Ki\u201067 in tumors of the ampulla of 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