{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:24:58Z","timestamp":1784226298762,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2003,10,9]],"date-time":"2003-10-09T00:00:00Z","timestamp":1065657600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> \u2003Microcystic adnexal carcinoma (MAC) was first described as a specific entity in 1982 by Goldstein <jats:italic>et\u2003al<\/jats:italic>. MAC is a\u2003very aggressive tumour, displaying locally invasive tendencies with perineural invasion. For this reason previous studies have suggested that Mohs micrographic surgery is a superior technique in establishing clear margins of excision. However, there is no evidence to suggest that standard local excision is less effective in achieving tumour clearance or a more favourable outcome.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> \u2003All patients with MAC were identified from the pathology database. All patients who had undergone local excision were reviewed and included in the study. Histopathology was reviewed by dermatopathologists.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> \u2003We reviewed the outcome of 17 patients treated with local excision. Eleven were female and six were male with a mean age of 70\u2003years, and a mean follow up of 30\u2003months. Two patients in this series experienced recurrence after standard local excision. The mean lateral and depth margins were 7.69\u2003mm (range 0.2\u221221) and 4.66\u2003mm (range 1\u221214.5), respectively. Recurrence occurred in two out of three patients who had lateral clearance margins of less than 4\u2003mm. These two patients had evidence of perineural invasion on histopathology.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> \u2003In the present study, standard local excision is shown to be effective in tumour clearance for MAC with no recurrences provided there are lateral margins of at least 4\u2003mm. However, a longer period of follow up is required because of the very aggressive locally invasive nature of the tumour.<\/jats:p>","DOI":"10.1046\/j.1445-2197.2003.02780.x","type":"journal-article","created":{"date-parts":[[2003,10,16]],"date-time":"2003-10-16T00:39:35Z","timestamp":1066264775000},"page":"830-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Will MAC be back?"],"prefix":"10.1111","volume":"73","author":[{"given":"Stephen","family":"Salerno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Terrill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,9]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820801)50:3<566::AID-CNCR2820500330>3.0.CO;2-Q"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.11.1355"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70053-8"},{"key":"e_1_2_8_5_2","first-page":"48","article-title":"Microcystic adnexal carcinoma: a report of three cases","volume":"43","author":"Kumar K","year":"1998","journal-title":"J. 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