{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:29:39Z","timestamp":1773656979495,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":541,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transgenic mice overexpressing either the mouse \u03b32L or \u03b32S subunit of the GABA<jats:sub>A<\/jats:sub> receptor were generated in a C57BL\/6\u2003J\u2003\u00d7\u2003DBA\/2\u2003J mixed background and expanded into transgenic lines. Transgenic mice and littermate controls were analysed with respect to altered behaviour indicative of anxiety, motor activity and acute effects of benzodiazepines and alcohol, as well as with regard to altered responses to alcohol withdrawal and acute functional tolerance to alcohol. Biochemical tests assessed flunitrazepam\u2010 and ethanol\u2010enhanced <jats:sup>36<\/jats:sup>Cl<jats:sup>\u2013<\/jats:sup> flux stimulated by muscimol in cerebellar and cortical microsacs and [<jats:sup>3<\/jats:sup>H]\u2010flunitrazepam binding to cerebellar membranes. There were no significant differences in any of these measures between the transgenic and control mice, except in tests of acute functional tolerance to acute injection of ethanol. Compared to controls, mice carrying either the \u03b32L or \u03b32S transgene developed significantly less tolerance to the ataxic effects of ethanol. We conclude that acute functional tolerance to ethanol is very sensitive to the amount of GABA<jats:sub>A<\/jats:sub> receptor \u03b32 subunit available (regardless of whether it is \u03b32L or \u03b32S) but overexpression of neither subunit isoform alters other behavioural and biochemical phenotypes.<\/jats:p>","DOI":"10.1046\/j.1460-9568.2000.00160.x","type":"journal-article","created":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T14:33:05Z","timestamp":1046961185000},"page":"2634-2638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Behavioural changes produced by transgenic overexpression of \u03b32L and \u03b32S subunits of the GABA<sub>A<\/sub> receptor"],"prefix":"10.1111","volume":"12","author":[{"given":"Marilee J.","family":"Wick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Radcliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J.","family":"Bowers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paola","family":"Mascia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"L\u00fcscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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