{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:05:13Z","timestamp":1773864313936,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":3204,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebral blood flow (CBF) and cerebral autoregulation have been investigated 24\u2003h after transient focal ischaemia in the rat. Cerebral blood flow was measured autoradiographically before and during a moderate hypotensive challenge, to test autoregulatory responses, using two CBF tracers, <jats:sup>99m<\/jats:sup>Tc\u2010d,l\u2010hexamethylproyleneamine oxide and <jats:sup>14<\/jats:sup>C\u2010iodoantipyrine. Prior to induced hypotension, CBF was significantly reduced within areas of infarction; cortex (28\u2003\u00b1\u200320 compared with 109\u2003\u00b1\u200323 mL\/100\u2003g\/min contralateral to ischaemic focus, P\u2003=\u20030.001) and caudate (57\u2003\u00b1\u200331 compared with 141\u2003\u00b1\u200332 mL\/100\u2003g\/min contralaterally, P\u2003=\u20030.005). The hypotensive challenge (mean arterial pressure reduced to 60\u2003mmHg by increasing halothane concentration) did not compromise grey matter autoregulation in the contralateral hemisphere; CBF data were not significantly different at normotension and during hypotension. However, in the ipsilateral hemisphere, a significant volume of cortex adjacent to the infarct, which exhibited normal flow at normotension, became oligaemic during the hypotensive challenge (e.g. frontal parietal cortex 109\u2003\u00b1\u200315% to 65\u2003\u00b1\u200315% of cerebellar flow, P\u2003&lt;\u20030.01). This resulted in a 2.5\u2010fold increase in the volume of cortex which fell below 50% cerebellar flow (39\u2003\u00b1\u200334 to 97\u2003\u00b1\u200346\u2003mm<jats:sup>3<\/jats:sup>, P\u2003=\u20030.003). Moderate hypotension induced a significant reduction in CBF in both ipsilateral and contralateral subcortical white matter (P\u2003&lt;\u20030.01). In peri\u2010infarct caudate tissue, CBF was not significantly affected by hypotension. In conclusion, a significant volume of histologically normal cortex within the middle cerebral artery territory was found to have essentially normal levels of CBF but impaired autoregulatory function at 24\u2003h post\u2010ischaemia.<\/jats:p>","DOI":"10.1046\/j.1460-9568.2000.00880.x","type":"journal-article","created":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T14:26:37Z","timestamp":1046960797000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Impaired cerebral autoregulation 24\u2003h after induction of transient unilateral focal ischaemia in the rat"],"prefix":"10.1111","volume":"12","author":[{"given":"D. G.","family":"MacGregor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. V. O.","family":"Carswell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. I.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"McCulloch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M.","family":"Macrae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.38.4.800"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.11.2235"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.1.26"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.9.6.569"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.930"},{"key":"e_1_2_6_7_1","first-page":"384","article-title":"Cerebral blood flow in severe clinical head injury","volume":"3","author":"Bouma G.J.","year":"1995","journal-title":"New Horiz."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.9.1372"},{"key":"e_1_2_6_9_1","first-page":"121","article-title":"Early and late systemic hypotension as a frequent and fundamental source of cerebral ischemia following severe brain injury in the Traumatic Coma Data Bank","volume":"59","author":"Chesnut R.M.","year":"1993","journal-title":"Acta Neurochir. (Suppl. Wien)"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.1.176"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb16201.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)11226-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00280-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00691287"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.61"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.12.1166"},{"key":"e_1_2_6_17_1","first-page":"101","volume-title":"Vascular Diseases of the Central Nervous System.","author":"Fieschi C.","year":"1983"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.37.5.550"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.39.10.1014"},{"key":"e_1_2_6_20_1","first-page":"728","article-title":"Brain microvessels: factors altering their patency after the occlusion of a middle cerebral artery (Wistar rat)","volume":"145","author":"Garcia J.H.","year":"1994","journal-title":"Am. J. Pathol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238114"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)12236-2"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6635"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001010050148"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.60.1.102"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.29.5.398"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.53"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)92199-4"},{"key":"e_1_2_6_29_1","first-page":"281","article-title":"Autoregulation impairment in non\u2010infarcted cortex, 24 hours after transient focal cerebral ischaemia","volume":"29","author":"Macgregor D.G.","year":"1998","journal-title":"Stroke"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90474-2"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.123"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.34"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199808000-00004"},{"key":"e_1_2_6_34_1","first-page":"H879","article-title":"Responses of cerebral arteries after ischemia and reperfusion in cats","volume":"255","author":"Mayhan W.G.","year":"1988","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.54.3.0289"},{"key":"e_1_2_6_36_1","first-page":"H670","article-title":"Brain blood flow autoregulation and metabolism during halothane anaesthesia in monkeys","volume":"233","author":"Morita H.","year":"1977","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005474"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1996.13.439"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1996.tb05579.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(96)80179-0"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.39.3.221"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.3.332"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.4.402"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.20.2.125"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.20.1.63"},{"key":"e_1_2_6_46_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/00365599.1984.11783712","article-title":"Converting enzyme inhibition and autoregulation of cerebral blood flow in spontaneously hypertensive and normotensive rats","volume":"79","author":"Strandgaard S.","year":"1984","journal-title":"Scand. J. Urol. Nephrol. Supplement"},{"key":"e_1_2_6_47_1","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1097\/00005344-199219006-00014","article-title":"Regulation of cerebral blood flow in health and disease","volume":"19","author":"Strandgaard S.","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198404000-00002"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.1996.tb00270.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00096-4"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.124"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1460-9568.2000.00880.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1460-9568.2000.00880.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:00:45Z","timestamp":1696330845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1460-9568.2000.00880.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1046\/j.1460-9568.2000.00880.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1460-9568.2000.00880.x","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"2008-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}