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Cox\u20101 immunolabelling was almost exclusively restricted to small diameter DRG neurons (&lt;\u20031000\u2003\u03bcm<jats:sup>2<\/jats:sup>), and was extensively colocalized with calcitonin gene\u2010related peptide (CGRP) and isolectin B4 (IB4). Cox\u20101 was present in 65% and 70% of CGRP\u2010 and IB4\u2010labelled neurons, respectively. Cox\u20101 labelling was also found in neurons expressing the sensory neuron\u2010specific (SNS) Na<jats:sup>+<\/jats:sup> channel. Cox\u20102 labelling was absent in DRG from normal rats. In the Freund's adjuvant model of monoarthritis, the proportion of cox\u20101\u2010positive DRG neurons was unchanged and no neurons were found to be labelled for cox\u20102. In primary tissue culture, cox\u20101 immunolabelling persisted in vitro for up to 9\u2003days and was present in morphologically identical neurons. The selective expression of cox\u20101 in peripheral ganglia was confirmed by the small number of nodose ganglion neurons and superior cervical ganglion (SCG) neurons labelled for cox\u20101. These data suggest that cox\u20101 is a marker for a subpopulation of putative nociceptive neurons in vitro and in vivo, and suggests that the prostaglandins synthesized by these neurons may be important for nociceptor function. These data may have important implications for the mode and mechanism of action of non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs).<\/jats:p>","DOI":"10.1046\/j.1460-9568.2000.00979.x","type":"journal-article","created":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T14:30:35Z","timestamp":1046961035000},"page":"911-920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Cyclooxygenase\u20101 is a marker for a subpopulation of putative nociceptive neurons in rat dorsal root ganglia"],"prefix":"10.1111","volume":"12","author":[{"given":"B.","family":"Chopra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Giblett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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