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Weak or strong ON shock\u2010evoked fluorescence transients always had short latency with an onset 0\u201310\u2003ms after the onset of the bulb local field potential, rapidly increasing to a peak of up to 25% fractional fluorescence change (\u0394F\/F) in 10\u201330\u2003ms, were blocked by 10\u2003\u00b5<jats:sc>m<\/jats:sc> CNQX, decaying with a time constant of about 1\u2003s. With stronger ON shocks that activated many receptor axons, an additional, delayed, sustained AP5\u2010sensitive component (peak at \u2248\u200a0.5\u2003s, up to 40% \u0394F\/F maximum) could usually be produced. Odour\u2010evoked [Ca<jats:sup>2+<\/jats:sup>] transients sometimes displayed a rapid onset phase that peaked within 50\u2003ms but always had a sustained phase that peaked 0.5\u20131.5\u2003s after onset, regardless of the strength of the odour or the amplitude of the response. These were considerably larger (up to 150% \u0394F\/F) than those evoked by ON shock. Odour\u2010evoked [Ca<jats:sup>2+<\/jats:sup>] transients were also distinguished from ON shock\u2010evoked transients by tufts in different glomeruli responding with different delays (time to onset differed by up to 1.5\u2003s between different tufts for the same odour). Odour\u2010evoked [Ca<jats:sup>2+<\/jats:sup>] transients were increased by AMPA\u2010kainate receptor blockade, but substantially blocked by AP5. Electrical stimulation of the lateral olfactory tract (5\u20136 stimuli at 10\u2003Hz) that evoked granule cell feedback inhibition, blocked 60\u2013100% of the odour\u2010evoked [Ca<jats:sup>2+<\/jats:sup>] transient in tufts when delivered within about 0.5\u2003s of the odour. LOT\u2010mediated inhibition was blocked by 10\u2003\u00b5<jats:sc>m<\/jats:sc> bicuculline.<\/jats:p>","DOI":"10.1046\/j.1460-9568.2001.01545.x","type":"journal-article","created":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T14:39:46Z","timestamp":1046961586000},"page":"1658-1672","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Odour\u2010evoked [Ca<sup>2+<\/sup>] transients in mitral cell dendrites of frog olfactory glomeruli"],"prefix":"10.1111","volume":"13","author":[{"given":"Kerry","family":"Delaney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Davison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Denk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1942.sp003955"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(96)00706-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.1.489"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199607290-00033"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.71.6.2557"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.6.1948"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.359be.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1523\/JNEUROSCI.18-12-04560.1998","article-title":"Odorant response properties of convergent olfactory receptor neurons","volume":"18","author":"Bozza T.C.","year":"1998","journal-title":"J. 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