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Electrical stimulation of the contralateral medial lemniscus and of the skin at sites evoking responses with minimal threshold induced recurrent activation of CL cells at a latency of 1\u20133.5\u2003ms. The lemniscal feedback activation was suppressed by increasing the stimulating intensity at the same sites, suggesting recurrent\u2010mediated lateral inhibition. The glycine antagonist strychnine blocked the recurrent excitatory responses while GABA<jats:sub>A<\/jats:sub> antagonists uncovered those obscured by stronger stimulation. CL cells sharing a common receptive field (RF) potentiate one another by recurrent activation and disinhibition, the disinhibition being produced by serial interactions between glycinergic and GABAergic interneurons. Conversely, CL cells with different RFs inhibit each other through recurrent GABA\u2010mediated inhibition. The lemniscal feedback would thus enhance the surround antagonism of a centre response by increasing the spatial resolution and the transmission of weak signals.<\/jats:p>","DOI":"10.1046\/j.1460-9568.2002.02230.x","type":"journal-article","created":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T14:50:05Z","timestamp":1046962205000},"page":"1697-1704","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The lemniscal\u2013cuneate recurrent excitation is suppressed by strychnine and enhanced by GABA<sub>A<\/sub> antagonists in the anaesthetized cat"],"prefix":"10.1111","volume":"16","author":[{"given":"Juan","family":"Aguilar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casto","family":"Rivadulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Canedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,13]]},"reference":[{"key":"e_1_2_6_2_1","article-title":"Pharmacological study of the cortical influences exerted on cuneate neurons of the anaesthetised cat","volume":"27","author":"Aguilar J.","year":"2001","journal-title":"Soc. 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