{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:37:43Z","timestamp":1791268663404,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,4,23]],"date-time":"2003-04-23T00:00:00Z","timestamp":1051056000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To help understand how the cortical map is set up during the early stages of corticogenesis, we have examined the developmental fate of embryonic day (E) 12 cortical progenitors in the rat. We have analysed the pattern of thalamic connections and cytoarchitectonic organization developed by progenitor cells removed at E12 from the presumptive parietal or occipital cortex and grafted into the parietal cortex of newborn hosts. Occipital progenitors grafted into the parietal cortex differentiated into neurons that developed reciprocal connections with the ventrobasal complex of the host thalamus. They could also form barrel\u2010like structures, within which axons of the ventrobasal complex were distributed in dense patches. Some of these barrel\u2010like structures were arranged in rows. Moreover, these progenitors failed to develop characteristic traits of occipital cortex cells as they did not establish connections with the dorsal lateral geniculate nucleus. We propose that cortical progenitors are not committed at E12 and, upon heterotopic transplantation, have the capacity to respond to local cues and to subsequently differentiate and maintain major phenotypic characteristics of neurons in their new environment. Only early progenitors are multipotent. By E13\/E14, indeed, most cortical cells become irreversibly committed and upon heterotopic transplantation differentiate neurons with phenotypic characteristics of their cortical site of origin (Pinaudeau <jats:italic>et\u00a0al<\/jats:italic>., 2000, <jats:italic>Eur. J. Neurosci.<\/jats:italic>, <jats:bold>12<\/jats:bold>, 2486\u20132496).<\/jats:p>","DOI":"10.1046\/j.1460-9568.2003.02576.x","type":"journal-article","created":{"date-parts":[[2003,5,30]],"date-time":"2003-05-30T08:54:41Z","timestamp":1054284881000},"page":"1375-1383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Early (E12) cortical progenitors can change their fate upon heterotopic transplantation"],"prefix":"10.1111","volume":"17","author":[{"given":"Afsaneh","family":"Gaillard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Nasarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Roger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(97)00197-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-02-00519.1991"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.9.3706"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1523\/JNEUROSCI.15-03-01819.1995","article-title":"Age dependent specification of the corticocortical connections of cerebral grafts","volume":"15","author":"Barbe M.F.","year":"1995","journal-title":"J. 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