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The aim of the present study was to investigate whether these rat lines differ in their susceptibility to morphine\u2010induced behavioural and neurochemical sensitization. The rats were given 15 injections of morphine (10\u2003mg\/kg, s.c.) or saline every other day. Locomotor activity and release of dopamine in the nucleus accumbens were monitored after a challenge with additional morphine injections (10\u2003mg\/kg) 1 and 5\u2003weeks after withdrawal from the repeated treatment. Morphine increased locomotion more in the previously morphine\u2010treated rats than in the saline\u2010treated controls. Furthermore, AA rats were more sensitive to this effect of morphine than ANA rats. Accumbal morphine\u2010induced dopamine release was significantly higher in the morphine\u2010treated AA than ANA rats after the first challenge injection 1\u2003week from withdrawal, but no differences were observed after the second challenge. The brain and plasma concentrations of morphine were similar among the lines suggesting that the differences in the effects of morphine cannot be explained in terms of differential pharmacokinetics of morphine in these lines. These data show that AA rats are more susceptible to morphine\u2010induced behavioural sensitization than ANA rats. Furthermore, it suggests that mesolimbic dopamine has at best only a transient role in the expression of opioid\u2010induced behavioural sensitization. The relationship between the mechanisms underlying the differential sensitivity of these rat lines to the effects of repeated morphine and voluntary ethanol drinking remains to be determined.<\/jats:p>","DOI":"10.1046\/j.1460-9568.2003.02589.x","type":"journal-article","created":{"date-parts":[[2004,12,23]],"date-time":"2004-12-23T05:58:19Z","timestamp":1103781499000},"page":"1655-1663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Differential behavioural sensitization to intermittent morphine treatment in alcohol\u2010preferring AA and alcohol\u2010avoiding ANA rats: role of mesolimbic dopamine"],"prefix":"10.1111","volume":"17","author":[{"given":"Sami","family":"Ojanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meri","family":"Koistinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"B\u00e4ckstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aino","family":"Kankaanp\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi","family":"Tuomainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petri","family":"Hyyti\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalervo","family":"Kiianmaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,4,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10033.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1972.tb06866.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(83)90080-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(89)90324-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb09067.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00466-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00524-9"},{"key":"e_1_2_7_9_1","first-page":"226","article-title":"Dopamine\u2010independent locomotion following blockade of N\u2010methyl\u2010d\u2010aspartate receptors in the ventral tegmental area","volume":"298","author":"Cornish J.L.","year":"2001","journal-title":"J. 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