{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T17:44:16Z","timestamp":1751823856607},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,7,22]],"date-time":"2003-07-22T00:00:00Z","timestamp":1058832000000},"content-version":"vor","delay-in-days":536,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p> <jats:bold>TOUSSAINT, J\u2010F., <jats:sc>et al.<\/jats:sc>: Ventricular Coupling of Electrical and Mechanical Dyssynchronization in Heart Failure Patients.<\/jats:bold> We studied the relationships of electrical and mechanical synchronization in patients with heart failure (CHF) and various degree of ventricular conduction delays. Ninety\u2010two CHF patients (<jats:styled-content>60 \u00b1 13<\/jats:styled-content> years old, <jats:styled-content>LVEF &lt; 45%<\/jats:styled-content>), NYHA II\u2010III\u2010IV, and 35 age\u2010matched control subjects were studied with angioscintigraphic phase analysis. We measured ejection fractions (LVEF, RVEF) and calculated the total activation time for the left (TtLV) and right ventricle (TtRV), and the synchronization time between right and left ventricle (TRVLV), and between LV apex and base (Tab). Patients were divided into three groups according to QRS duration: <jats:styled-content>group 1 &lt; 120 ms<\/jats:styled-content> (<jats:styled-content>n = 28<\/jats:styled-content>), <jats:styled-content>group 2 &lt; 150 ms<\/jats:styled-content> (<jats:styled-content>n = 23<\/jats:styled-content>), <jats:styled-content>group 3 \u2265 150 ms<\/jats:styled-content> (<jats:styled-content>n = 41<\/jats:styled-content>). In group 1: <jats:styled-content>LVEF = 31.1 \u00b1 10.9%<\/jats:styled-content>, <jats:styled-content>RVEF = 30.1 \u00b1 12.6%<\/jats:styled-content>, <jats:styled-content>TtLV = 204 \u00b1 70 ms<\/jats:styled-content>, <jats:styled-content>TtRV = 183 \u00b1 61 ms<\/jats:styled-content>, <jats:styled-content>TRVLV = 7 \u00b1 33 ms<\/jats:styled-content>, <jats:styled-content>Tab = 29 \u00b1 23 ms<\/jats:styled-content>. In group 2, these <jats:styled-content>were: 27.8 \u00b1 9.1%<\/jats:styled-content>, <jats:styled-content>27.8 \u00b1 8.8%<\/jats:styled-content>, <jats:styled-content>227 \u00b1 95 ms<\/jats:styled-content>, <jats:styled-content>248 \u00b1 137 ms<\/jats:styled-content>, <jats:styled-content>35 \u00b1 42 ms*<\/jats:styled-content>, <jats:styled-content>and 39 \u00b1 53 ms<\/jats:styled-content> respectively. In group 3: <jats:styled-content>LVEF = 20.5 \u00b1 9.5%\u2020<\/jats:styled-content>, <jats:styled-content>RVEF = 28.4 \u00b1 16.1%<\/jats:styled-content>, <jats:styled-content>TtLV = 304 \u00b1 155 ms\u2020<\/jats:styled-content>, <jats:styled-content>TtRV = 234 \u00b1 106 ms\u2020<\/jats:styled-content>, <jats:styled-content>TRVLV = 64 \u00b1 42 ms\u2020<\/jats:styled-content>, and <jats:styled-content>Tab = 67 \u00b1 48 ms*<\/jats:styled-content>, all <jats:styled-content>P &lt; 0.001<\/jats:styled-content> versus controls <jats:styled-content>*P &lt; 0.05<\/jats:styled-content> versus G1, <jats:styled-content>\u2020P \u2264 0.01 versus G1<\/jats:styled-content>. A significant relation links QRS to both inter\u2010 and intraventricular asynchrony (TRVLV: <jats:styled-content>r = 0.65<\/jats:styled-content>; TtLL: <jats:styled-content>r = 0.70<\/jats:styled-content>, Tab: <jats:styled-content>r = 0.60<\/jats:styled-content>), and to LV function (<jats:styled-content>r = 0.72<\/jats:styled-content>); while LVEF relates more closely to intraventricular asynchrony: TtLV (<jats:styled-content>r = 0.52<\/jats:styled-content>), TtLL (<jats:styled-content>r = 0.67<\/jats:styled-content>), than to interventricular asynchrony: TRVLV (<jats:styled-content>r = 0.48<\/jats:styled-content>); <jats:styled-content>P &lt; 0.01<\/jats:styled-content>, <jats:styled-content>P \u2264 0.001<\/jats:styled-content>. In CHF patients, electromechanical and contractile alterations are coupled; regional activation may be an early parameter allowing the detection of ventricular dyssynchronization.<\/jats:p>","DOI":"10.1046\/j.1460-9592.2002.00178.x","type":"journal-article","created":{"date-parts":[[2003,7,22]],"date-time":"2003-07-22T13:34:00Z","timestamp":1058880840000},"page":"178-182","source":"Crossref","is-referenced-by-count":12,"title":["Ventricular Coupling of Electrical and Mechanical Dyssynchronization in Heart Failure Patients"],"prefix":"10.1111","volume":"25","author":[{"given":"JEAN\u2010FRAN\u00c7OIS","family":"TOUSSAINT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS","family":"LAVERGNE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KHALDOUN","family":"KERROU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARBARA","family":"DE DIEULEVEULT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FELIZARDO","family":"PONCE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARC","family":"FROISSART","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN\u2010YVES","family":"LE HEUZEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LOUIS","family":"GUIZE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHEL","family":"PAILLARD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,7,22]]},"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1460-9592.2002.00178.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1460-9592.2002.00178.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T12:24:28Z","timestamp":1700396668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1460-9592.2002.00178.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1046\/j.1460-9592.2002.00178.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1460-9592.2002.00178.x","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}