{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:45:57Z","timestamp":1762112757177},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,1,13]],"date-time":"2002-01-13T00:00:00Z","timestamp":1010880000000},"content-version":"vor","delay-in-days":652,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:title>Abstracts<\/jats:title><jats:p> <jats:bold>Aims<\/jats:bold>\u2003Sorbitol and <jats:italic>myo<\/jats:italic>\u2010inositol levels and morphology of sural nerve were compared with nerve function and clinical neuropathy in men with diabetic, impaired (IGT), and normal glucose tolerance.<\/jats:p><jats:p> <jats:bold>Methods<\/jats:bold>\u2003After neurography of sural nerve and determinations of sensory thresholds for vibration, warm and cold on the foot, whole nerve sural nerve biopsy was performed in 10 men with Type 1 diabetes mellitus, 10 with IGT, and 10 with normal glucose tolerance. Polyol levels were assessed by gas\u2013liquid chromatography\/mass spectrometry.<\/jats:p><jats:p> <jats:bold>Results<\/jats:bold>\u2003Sural nerve amplitudes were significantly lower and sorbitol levels significantly higher in diabetic patients (median (interquartile range)) (3.7 (3.5)\u2003\u03bcV and 643 (412) pmol\/mg protein, respectively) both compared with IGT (11.3 (10.6)\u2003\u03bcV; <jats:italic>P<\/jats:italic>\u2003=\u20030.04 and 286 (83) pmol\/mg protein; <jats:italic>P<\/jats:italic>\u2003=\u20030.0032, respectively) and normally glucose tolerant (10.0 (11.6); <jats:italic>P<\/jats:italic>\u2003=\u20030.0142 and 296 (250) pmol\/mg protein; <jats:italic>P<\/jats:italic>\u2003=\u20030.0191, respectively) subjects. There were no differences in nerve morphology between the three groups. Nerve <jats:italic>myo<\/jats:italic>\u2010inositol levels correlated, however, positively with cluster density (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2003=\u20030.56; <jats:italic>P<\/jats:italic>\u2003=\u20030.0054). In diabetic and IGT subjects, sural nerve amplitudes (2.6 (3.8) vs. 12.1 (10.6)\u2003\u03bcV; <jats:italic>P<\/jats:italic>\u2003=\u20030.0246) and myelinated nerve fibre density (MNFD; 4076 (1091) vs. 5219 (668) nerve fibres\/mm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2003=\u20030.0021) were significantly lower in nine subjects with clinical neuropathy than in 10 without.<\/jats:p><jats:p> <jats:bold>Conclusions<\/jats:bold>\u2003Nerve degeneration (i.e. MNFD) correlated with clinical neuropathy but not with glucose tolerance status whereas nerve <jats:italic>myo<\/jats:italic>\u2010inositol levels positively correlated with signs of nerve regeneration (i.e. increased cluster density).<\/jats:p>","DOI":"10.1046\/j.1464-5491.2000.00261.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T14:44:13Z","timestamp":1047393853000},"page":"259-268","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Sorbitol and <i>myo<\/i>\u2010inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance"],"prefix":"10.1111","volume":"17","author":[{"given":"G.","family":"Sundkvist","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. \u2010B.","family":"Dahlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. \u2010F.","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lindg\u00e4rde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Ros\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Lattimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A. F.","family":"Sima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,13]]},"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1464-5491.2000.00261.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1464-5491.2000.00261.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T03:14:08Z","timestamp":1695870848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1464-5491.2000.00261.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1046\/j.1464-5491.2000.00261.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1464-5491.2000.00261.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]},"assertion":[{"value":"2002-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}