{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T07:56:34Z","timestamp":1794556594160,"version":"4.9.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2002,1,13]],"date-time":"2002-01-13T00:00:00Z","timestamp":1010880000000},"content-version":"vor","delay-in-days":561,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p> <jats:bold>SUMMARY<\/jats:bold> <\/jats:p><jats:p><jats:bold>Aims\u2003<\/jats:bold> To assess maternal and neonatal complications in pregnancies of diabetic women treated with oral hypoglycaemic agents during pregnancy.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> A cohort study including all consecutively registered, orally treated pregnant diabetic patients set in a diabetic obstetrical service at a university hospital: 50 women treated with metformin, 68 women treated with sulphonylurea during pregnancy and a reference group of 42 diabetic women treated with insulin during pregnancy.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> The prevalence of pre\u2010eclampsia was significantly increased in the group of women treated with metformin compared to women treated with sulphonylurea or insulin (32 vs. 7 vs. 10%, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). No difference in neonatal morbidity was observed between the orally treated and insulin\u2010treated group; no cases of severe hypoglycaemia or jaundice were seen in the orally treated groups. However, in the group of women treated with metformin in the third trimester, the perinatal mortality was significantly increased compared to women not treated with metformin (11.6 vs. 1.3%, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.02).<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> Treatment with metformin during pregnancy was associated with increased prevalence of pre\u2010eclampsia and a high perinatal mortality.<\/jats:p>","DOI":"10.1046\/j.1464-5491.2000.00314.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T14:46:05Z","timestamp":1047393965000},"page":"507-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Oral hypoglycaemic agents in 118 diabetic pregnancies"],"prefix":"10.1111","volume":"17","author":[{"given":"E.","family":"Hellmuth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Damm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"M\u00f8lsted\u2010Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1,13]]},"reference":[{"issue":"2","key":"e_1_2_6_2_2","first-page":"123","article-title":"Summary and recommandations of the second International Workshop\u2010Conference on Gestational Diabetes Mellitus","volume":"34","author":"American Diabetes Association.","year":"1985","journal-title":"Diabetes"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.34.2.S13"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198610163151609"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.34.2.S66"},{"key":"e_1_2_6_6_2","first-page":"19","article-title":"Endocrine pancreatic function in women with gestational diabetes","volume":"122","author":"K\u00fchl C","year":"1986","journal-title":"Acta Endocrinol"},{"key":"e_1_2_6_7_2","first-page":"27","article-title":"Insulin receptors in normal pregnant women and women with gestational diabetes","volume":"122","author":"Andersen O","year":"1986","journal-title":"Acta Endocrinol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.243.696"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01221950"},{"key":"e_1_2_6_10_2","first-page":"11","article-title":"Practical screening for diabetes mellitus in pregnant women","volume":"75","author":"Guttorm E","year":"1974","journal-title":"Acta Endocrinol"},{"key":"e_1_2_6_11_2","first-page":"709","article-title":"Glucose metabolism during and after pregnancy in normal and gestational diabetic women. 1. 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