{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:53:37Z","timestamp":1761893617234},"reference-count":6,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2805,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p> <jats:bold>SUMMARY<\/jats:bold> <\/jats:p><jats:p><jats:bold>Case report\u2003<\/jats:bold> A 39\u2010year\u2010old man with Type 1 diabetes mellitus was hospitalized with severe diabetic ketoacidosis (DKA). Sixteen hours after admission he suddenly deteriorated having a respiratory then cardiac arrest. A brain computed tomography scan performed 2\u2003h after the respiratory arrest showed severe cerebral oedema. Serial serum samples were stored and analysed for S\u2010100\u03b2 protein. The S\u2010100\u03b2 protein concentration was initially normal (0.12 \u03bcg\/l) then rose significantly before the onset of the respiratory arrest (8.5\u2003h\u2003= 0.61\u2003\u03bcg\/l, 14.5\u2003h\u2003=\u20030.9\u2003\u03bcg\/l, 18\u2003h\u2003=\u20031.6\u2003\u03bcg\/l, 25.5\u2003h\u2003=\u20033.1\u2003\u03bcg\/l, 34\u2003h\u2003=\u20034.6\u2003\u03bcg\/l and 44\u2003h\u2003=\u200319.5\u2003\u03bcg\/l).<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> In this case of DKA, serum S\u2010100\u03b2 concentration rose coinciding with the onset of cerebral oedema, before it became clinically evident. Monitoring serum S\u2010100\u03b2 may have a useful role in the management of DKA.<\/jats:p><jats:p>Keywords cerebral oedema, diabetic ketoacidosis, S\u2010100\u03b2 protein<\/jats:p>","DOI":"10.1046\/j.1464-5491.2000.00370.x","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:21:58Z","timestamp":1027678918000},"page":"807-809","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Serum S\u2010100\u03b2 protein is a potential biochemical marker for cerebral oedema complicating severe diabetic ketoacidosis"],"prefix":"10.1111","volume":"17","author":[{"given":"E. A.","family":"McIntyre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. D.","family":"Abraha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Perros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Sherwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"437","article-title":"The S\u2010100 protein family","volume":"13","author":"Douglas K","year":"1988","journal-title":"TIBS"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(91)90040-L"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.5.911"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000456329703400405"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.2.473"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(97)90160-9"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1464-5491.2000.00370.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1464-5491.2000.00370.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T07:13:59Z","timestamp":1698563639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1464-5491.2000.00370.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":6,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["10.1046\/j.1464-5491.2000.00370.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1464-5491.2000.00370.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]},"assertion":[{"value":"2008-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}