{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T12:48:44Z","timestamp":1794055724160,"version":"4.8.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1046\/j.1467-2995.2003.00090.x","type":"journal-article","created":{"date-parts":[[2003,8,19]],"date-time":"2003-08-19T05:42:15Z","timestamp":1061271735000},"page":"220-228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"title":["A comparison of preoperative tramadol and morphine for the control of early postoperative pain in canine ovariohysterectomy"],"prefix":"10.1016","volume":"30","author":[{"given":"Sandra","family":"Mastrocinque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise T","family":"Fantoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1046\/j.1467-2995.2003.00090.x_bib25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/BF03009627","article-title":"A comparison of epidural tramadol and epidural morphine for postoperative analgesia","volume":"40","author":"Baraka","year":"1993","journal-title":"Can J Anaesth"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1532-950X.1991.tb00340.x","article-title":"Postoperative catecholamine response to onychectomy in isoflurane anesthetized cats \u2013 effect of analgesics","volume":"20","author":"Benson","year":"1991","journal-title":"Vet Surg"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib23","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1046\/j.1365-2885.1997.00060.x","article-title":"A comparison of preoperative morphine and buprenorphine for postoperative analgesia for arthrotomy in dogs","volume":"20","author":"Brodbelt","year":"1997","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib2","first-page":"353","article-title":"How to manage perioperative pain","volume":"91","author":"Carroll","year":"1996","journal-title":"Vet Med"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib4","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0195-5616(99)50056-9","article-title":"Analgesics and pain","volume":"29","author":"Carroll","year":"1999","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib38","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/archinte.1987.00370070087013","article-title":"Hormonal responses to a graded surgical stress","volume":"147","author":"Chernow","year":"1987","journal-title":"Arch Int Med"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s003810050019","article-title":"Preemptive analgesia with tramadol and fentanyl in pediatric neurosurgery","volume":"16","author":"Chiaretti","year":"2000","journal-title":"Childs Nerv Syst"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib26","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/bja\/81.5.737","article-title":"Tramadol or morphine administered during operation: a study of immediate postoperative abdominal hysterectomy","volume":"81","author":"Coetzee","year":"1998","journal-title":"Br J Anaesth"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2125.1996.tb00152.x","article-title":"Contribution of monoaminergic modulation to the analgesic effect of tramadol","volume":"41","author":"Desmeules","year":"1996","journal-title":"Br J Clin Pharmacol"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/bja\/81.1.51","article-title":"Remifentanil and tramadol","volume":"81","author":"Duthie","year":"1998","journal-title":"Br J Anaesth"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0034-5288(94)90091-4","article-title":"Changes in plasma cortisol concentrations before, during and after analgesia, anaesthesia and anaesthesia plus ovariohysterectomy in bitches","volume":"57","author":"Fox","year":"1994","journal-title":"Res Vet Sci"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib5","first-page":"254","article-title":"Is postoperative pain management important in dogs and cats?","volume":"3","author":"Gaynor","year":"1999","journal-title":"Vet Med"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib6","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2460\/javma.1999.215.08.1105","article-title":"Comparison of ketoprofen and carprofen administered prior to orthopedic surgery for control of postoperative pain in dogs","volume":"215","author":"Grisneaux","year":"1999","journal-title":"J Am Vet Med Assoc"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib40","series-title":"Kirk's Current Veterinary Therapy XIII\u2010Small Animal Practice","first-page":"57","article-title":"Acute Pain Management","author":"Hendrix","year":"2000"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib11","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2460\/javma.1996.209.03.598","article-title":"Epidural administration of bupivacaine, morphine, or their combination for postoperative analgesia in dogs","volume":"209","author":"Hendrix","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib30","first-page":"877","article-title":"Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids","volume":"38","author":"Hennies","year":"1988","journal-title":"Drugs"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib14","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1213\/00000539-199204000-00007","article-title":"Efficacy and safety of tramadol versus morphine for moderate and severe postoperative pain with special regard to respiratory depression","volume":"74","author":"Houmes","year":"1992","journal-title":"Anesth Analg"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib36","series-title":"Assessment of Adrenal and Thyroid Function in the Canine Species: Determination of Normal Values for Three Different Immunoassays. PhD Thesis","first-page":"131","author":"Jeric\u00f3","year":"1998"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib19","series-title":"Clinical Biochemistry of Domestic Animals","author":"Kaneko","year":"1997"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib7","first-page":"2","article-title":"Perioperative analgesia\u2010opioids and NSAIDs","volume":"9","author":"Lascelles","year":"1999","journal-title":"Waltham Focus"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/vr.134.8.187","article-title":"Postoperative analgesic and sedative effects of carprofen and pethidine in dogs","volume":"134","author":"Lascelles","year":"1994","journal-title":"Vet Rec"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/inpract.19.4.203","article-title":"Analgesia in cats","volume":"19","author":"Lascelles","year":"1997","journal-title":"In Prac"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2165\/00003495-199346020-00008","article-title":"Tramadol. A preliminary review of its pharmacodynamic and its pharmacokinetic properties, and therapeutic potential in acute and chronic pain states","volume":"46","author":"Lee","year":"1993","journal-title":"Drugs"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib33","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.2460\/ajvr.1993.54.10.1721","article-title":"Influence of anesthetic regimens on the perioperative catecholamine response associated with onychectomy in cats","volume":"54","author":"Lin","year":"1993","journal-title":"Am J Vet Res"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib29","first-page":"1932","article-title":"Biotransformation of tramadol in man and animal","volume":"31","author":"Lintz","year":"1981","journal-title":"Drugs"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib21","first-page":"539","article-title":"Nonsteroidal and anti\u2010inflamatory analgesics in pain management in dogs and cats","volume":"37","author":"Mathews","year":"1996","journal-title":"Can Vet J"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib9","first-page":"557","article-title":"A comparison of ketorolac with flunixin, butorphanol, and oxymorphone in controlling postoperative pain in dogs","volume":"37","author":"Mathews","year":"1996","journal-title":"Can Vet J"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0952-8180(99)00047-1","article-title":"Effects of tramadol and meperidine on respiration, plasma catecholamine concentrations, and hemodynamics","volume":"11","author":"Mildh","year":"1999","journal-title":"J Clin Anesth"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/vr.116.16.431","article-title":"Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment","volume":"116","author":"Morton","year":"1985","journal-title":"Vet Rec"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib41","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/BF03012458","article-title":"Perioperative antinociceptive effects of tramadol. A prospective, randomized, double\u2010blind comparison with morphine","volume":"45","author":"Naguib","year":"1998","journal-title":"Can J Anaesth"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib22","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2460\/javma.1997.211.04.438","article-title":"Comparison of ketoprofen, oxymorphone hydrochloride, and butorphanol in the treatment of postoperative pain in dogs","volume":"211","author":"Pibarot","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1467-2995.1993.tb00104.x","article-title":"Efficacy of epidural morphine versus intravenous morphine for post\u2010thoracotomy pain in dogs","volume":"20","author":"Popilskis","year":"1993","journal-title":"J Vet Anaesth"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1096-2867(97)80004-7","article-title":"Recent advances in our understanding of pain: how should they affect management?","volume":"12","author":"Raffe","year":"1997","journal-title":"Semin Vet Med Surg (Small Anim)"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1532-950X.1989.tb01081.x","article-title":"Cardiovascular function and serum catecholamine concentrations after anesthesia and surgery in the dog","volume":"18","author":"Rawlings","year":"1989","journal-title":"Vet Surg"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib35","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2460\/ajvr.1996.57.11.1674","article-title":"Indicators of postoperative pain in cats and correlation with clinical criteria","volume":"57","author":"Smith","year":"1996","journal-title":"Am J Vet Res"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib16","first-page":"211","article-title":"Respiratory and analgesic effects of meperidine and tramadol in patients undergoing orthopedic surgery","volume":"18","author":"Tarradell","year":"1996","journal-title":"Meth Find Exp Clinl Pharmacol"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1748-5827.1984.tb03416.x","article-title":"Postoperative analgesia in the dog: a comparison of morphine, buprenorphine and pentazocine","volume":"25","author":"Taylor","year":"1984","journal-title":"J Small Anim Pract"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib39","series-title":"Essentials of Small Animal Anesthesia and Analgesia","first-page":"28","article-title":"Perioperative pain and its management","author":"Thurmon","year":"1999"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0028-2243(93)90260-J","article-title":"Tramadol in labor pain in primiparous patients. A prospective comparative clinical trial","volume":"49","author":"Viegas","year":"1993","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib27","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/00000542-199909000-00013","article-title":"Effects of morphine and tramadol on somatic and visceral sensory function and gastrointestinal motility after abdominal surgery","volume":"91","author":"Wilder\u2010Smith","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib42","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/bja\/83.5.780","article-title":"Effects of tramadol on minimum alveolar concentration (MAC) of isoflurane in rats","volume":"83","author":"Wolff","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1046\/j.1467-2995.2003.00090.x_bib31","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/00498250110057378","article-title":"Metabolism of the analgesic drug, tramadol hydrochloride, in the rat and dog","volume":"31","author":"Wu","year":"2001","journal-title":"Xenobiotica"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716310108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716310108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:55:44Z","timestamp":1761447344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298716310108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S1467298716310108"],"URL":"https:\/\/doi.org\/10.1046\/j.1467-2995.2003.00090.x","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparison of preoperative tramadol and morphine for the control of early postoperative pain in canine ovariohysterectomy","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1046\/j.1467-2995.2003.00090.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}