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In cases of familial acne inversa, the pattern of transmission and number of affected individuals are consistent with autosomal dominant inheritance. Aetiological factors such as hyperandrogenism, obesity, smoking and chemical irritants are not consistently associated with the affection. Bacterial involvement is not a primary event in acne inversa, but is secondary to the disease process. Potential complications include dermal contraction, local or systemic infection due to the spread of microorganisms, systemic amyloidosis, arthropathy, and squamous cell carcinoma. As spontaneous resolution is rare and progressive disability is the rule, early definitive surgical intervention is advisable. The surgical procedure of choice in most cases is wide local excision and healing by secondary intention. Pharmacotherapeutic drugs, including synthetic retinoids and antiandrogens, do not prevent progression of the disease.<\/jats:p>","DOI":"10.1046\/j.1468-3083.2001.00303.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T04:41:23Z","timestamp":1047444083000},"page":"532-540","source":"Crossref","is-referenced-by-count":97,"title":["Acne inversa (alias hidradenitis suppurativa)"],"prefix":"10.1111","volume":"15","author":[{"given":"T","family":"Jansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Altmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Plewig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,22]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00414.x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90321-7"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb02037.x"},{"key":"e_1_2_9_5_2","first-page":"365","volume-title":"Acne and Related Disorders","author":"Harrison BJ","year":"1989"},{"key":"e_1_2_9_6_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0094-1298(20)30608-8","article-title":"Hidradenitis suppurativa","volume":"14","author":"Paletta C","year":"1987","journal-title":"Clin Plast Surg"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800790905"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb03227.x"},{"key":"e_1_2_9_9_2","first-page":"91","volume-title":"Dictionnaire de M\u00e9decine, un R\u00e9pertoire G\u00e9n\u00e9ral des Sciences M\u00e9dicales sous la Rapport Th\u00e9orique et Practique","author":"Velpeau A","year":"1839"},{"key":"e_1_2_9_10_2","unstructured":"VerneuilA.\u00c9tudes sur les tumeurs de la peau et quelques maladies des glandes sudoripares.Arch G\u00e9n M\u00e9d1854;94:447\u2013468 693\u2013705."},{"key":"e_1_2_9_11_2","unstructured":"VerneuilA.De l\u2019hidrosad\u00e9nite phlegmoneuse et des abc\u00e9s sudoripares.Arch G\u00e9n M\u00e9d1864;114:537\u2013557 1865;115: 327\u2013337 437\u2013453."},{"key":"e_1_2_9_12_2","first-page":"319","article-title":"Unusual pyodermas (hidrosadenitis suppurativa, acne conglobata, dissecting cellulitis of the scalp). 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