{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:51:16Z","timestamp":1790373076409,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,3,14]],"date-time":"2002-03-14T00:00:00Z","timestamp":1016064000000},"content-version":"vor","delay-in-days":72,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> The two major subtypes of pemphigus include: pemphigus vulgaris (PV) and pemphigus foliaceus. Only limited data are available on the epidemiology of these diseases.<\/jats:p><jats:p><jats:bold>Objective<\/jats:bold> The aim of the present study was to estimate the gender\u2010 and age\u2010specific incidences of PV in two well\u2010defined regions of Germany and to compare the incidences among native Germans with those in citizens from other countries living in Germany.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> We performed a retrospective review of records from all patients that were diagnosed with PV at the Departments of Dermatology in W\u00fcrzburg and Mannheim between 1989 and 1997.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> During the observation period, 14 patients were diagnosed with PV coming from an area with 1.46 million residents. With regard to the patients\u2019 age, the highest incidence for women was found in the 51\u201365\u2010year\u2010old\u2010age group with 2.34 [95% confidence interval (CI): 0.36; 7.76] new cases per 1 million inhabitants per year. The highest incidence for men was observed in the over 65\u2010year\u2010old age group with 3.72 (95% CI: 0.95; 9.8) cases\/million per year. In the 51\u201365\u2010year\u2010old age group, we found a 25\u2010fold higher incidence of PV in foreigners living in Germany compared with native Germans. The age\u2010adjusted incidence of PV was ninefold higher in foreigners compared with native Germans. Interestingly, all non\u2010German patients came from two southern European countries (Turkey and Italy).<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> The age\u2010adjusted incidence of PV differs between native Germans and foreigners living in Germany. Further studies are necessary to address the risk factors (genetic and\/or environmental) that contribute to this difference.<\/jats:p>","DOI":"10.1046\/j.1468-3083.2002.00384.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T04:41:59Z","timestamp":1047444119000},"page":"68-71","source":"Crossref","is-referenced-by-count":52,"title":["Increased incidence of pemphigus vulgaris in southern Europeans living in Germany compared with native Germans"],"prefix":"10.1111","volume":"16","author":[{"given":"K","family":"Hahn\u2010Ristic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Rzany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Amagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E\u2010B","family":"Br\u00f6cker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Zillikens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,3,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(99)00016-X"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70183-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12337524"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.159.4.2010"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2340\/0001555562491496","article-title":"Pemphigus: an epidemiological study of patients treated in Finnish hospitals between 1969 and 1978","volume":"62","author":"Hietanen J","year":"1982","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_7_2","first-page":"1030","article-title":"Pemphigus \u2013 a review","volume":"33","author":"Lynch PJ","year":"1976","journal-title":"Ariz Med"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1001\/archderm.1980.01640330073017","article-title":"Pemphigus in Hartford County, Connecticut from 1972 to 1977","volume":"116","author":"Simon DG","year":"1980","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12612836"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb03519.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00864.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70061-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep13070394"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90365-X"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1989.tb00405.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1468-3083.2002.00384.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1468-3083.2002.00384.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T13:38:16Z","timestamp":1697549896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1468-3083.2002.00384.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1046\/j.1468-3083.2002.00384.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1468-3083.2002.00384.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}