{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:45:39Z","timestamp":1766065539349},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,10,2]],"date-time":"2002-10-02T00:00:00Z","timestamp":1033516800000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> Anal fissures are common and painful. Botulinum toxin A (BTXA) is considered to be the most potent non\u2010surgical treatment; however, no attention has been paid to associated hyperhidrosis.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> To compare traditional BTXA treatment of muscular spasticity in anal fissures with combined treatment of spasticity and focal hyperhidrosis of the anal fold and perianal skin.<\/jats:p><jats:p><jats:bold>Setting<\/jats:bold> Outpatient department of a dermatological hospital.<\/jats:p><jats:p><jats:bold>Patients and methods<\/jats:bold> Ten patients with chronic anal fissures (of more than 6\u00a0months duration who failed to respond to conservative treatment and who had refused surgery) associated with focal hyperhidrosis as assessed by Minor's sweat test were investigated in an open, two\u2010armed trial. Intramuscular injections of 20\u201325\u00a0U BTXA (Botox\u00ae) were performed in group A (<jats:italic>n<\/jats:italic>\u00a0=\u00a05). In group B (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) those injections were combined with intracutaneous injection of 30\u201350\u00a0U BTXA to treat focal hyperhidrosis. Mean follow\u2010up was 5\u00a0months.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> Five of five patients in group B but only two of five patients in group A experienced a complete remission despite the fact that relief of pain was evident in eight of 10 patients within 2\u00a0weeks. Patient satisfaction with treatment was high but slightly better in group B.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> This open trial suggests that combined therapy of both muscular spasticity and focal hyperhidrosis may provide better results than intramuscular injections alone in anal fissure therapy with BTXA.<\/jats:p>","DOI":"10.1046\/j.1468-3083.2002.00490.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T04:42:51Z","timestamp":1047444171000},"page":"469-471","source":"Crossref","is-referenced-by-count":17,"title":["Botulinum toxin A in anal fissures: a modified technique"],"prefix":"10.1111","volume":"16","author":[{"given":"U","family":"Wollina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Konrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,10,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70172-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900623"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388152"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00307-X"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02235041"},{"key":"e_1_2_5_7_2","first-page":"CD002199","article-title":"Operative procedures for fissure in ano (Cochrane Review)","volume":"3","author":"Nelson RL","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050816"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236691"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005682707182"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003840000230"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236977"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234710"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907083410201"},{"key":"e_1_2_5_15_2","first-page":"163","article-title":"The treatment of anal fissure with botulinum toxin [Spanish]","volume":"22","author":"Gonzalez Carro P","year":"1999","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801223380402"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199811000-00005"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236694"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026610910080"},{"key":"e_1_2_5_20_2","first-page":"977","article-title":"Topical nitrates and the higher doses of botulinum toxin for chronic anal fissure","volume":"48","author":"Madalinski MH","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00255-X"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050151"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007817"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00350.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1468-3083.2002.00490.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1468-3083.2002.00490.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T13:35:00Z","timestamp":1697549700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1468-3083.2002.00490.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1046\/j.1468-3083.2002.00490.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1468-3083.2002.00490.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}