{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:28:37Z","timestamp":1793039317745,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,10,24]],"date-time":"2003-10-24T00:00:00Z","timestamp":1066953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Erythema multiforme (EM) is an uncommon mucocutaneous disorder, characterized by widespread erythematous\u2010oedematous targetoid lesions, considered as a reaction pattern to many different stimuli.<\/jats:p><jats:p><jats:bold>Observation\u2002<\/jats:bold> Presentation is made of a classical EM eruption concomitant to an inflammatory, atypical dermatophytosis of the ala nasi, observed in a 37\u2010year\u2010old male at the Dermatology Department of Cagliari, Italy.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Laboratory investigations revealed normal complete blood count and biochemistry profile. A direct microscopic examination with 20% potassium hydroxide of the nasal skin scales and of the vibrissae indicated the presence of dermatophyte hyphae and spores invading the rhinothrix. Culture confirmed a <jats:italic>Trycophyton mentagrophytes<\/jats:italic> infection. Specific determination of antiviral immunity in the blood (TORCH) was negative for recent infections, while the cell\u2010mediated response, investigated with a delayed skin multitest, showed a marked positivity for the tricophyton antigen. Systemic therapy with terbinafine (250\u00a0mg\/day) led to complete clinical and mycological recovery of the atypical ringworm in 30\u00a0days. Multiforme lesions rapidly improved and completely disappeared in 7\u00a0days.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> ID reaction to a distant focus of dermatophyte infection very rarely presents as EM. The presented case fits all the essential criteria required for the diagnosis of an ID reaction. The atypical clinical presentation of the ringworm infection, with marked involvement of the intranasal hairs, seems to have induced an inflammatory allergic response, similar to that evoked by sycosis.<\/jats:p>","DOI":"10.1046\/j.1468-3083.2003.00698.x","type":"journal-article","created":{"date-parts":[[2003,10,24]],"date-time":"2003-10-24T10:15:18Z","timestamp":1066990518000},"page":"699-701","source":"Crossref","is-referenced-by-count":19,"title":["Erythema multiforme ID reaction in atypical dermatophytosis: a case report"],"prefix":"10.1111","volume":"17","author":[{"given":"L","family":"Atzori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Aste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,24]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"1834","volume-title":"Textbook of Dermatology","author":"Rook.","year":"1992"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.1999.10.15.763"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70141-2"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)80003-6"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247159"},{"key":"e_1_2_4_7_2","first-page":"1160","volume-title":"Textbook of Dermatology","author":"Hay RJ","year":"1992"},{"key":"e_1_2_4_8_2","first-page":"153","volume-title":"Medical Mycology","author":"Grigoriu D","year":"1987"},{"key":"e_1_2_4_9_2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2340\/0001555563404408","article-title":"Dermatophytid \u2013 a misdiagnosed entity?","volume":"63","author":"Kaaman T","year":"1983","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_4_10_2","first-page":"1133","article-title":"Cutaneous adverse effects associated with terbinafine therapy: 10 case reports and review of the literature","volume":"139","author":"Gupta AK","year":"1998","journal-title":"Br J Dermatol"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1995.tb01314.x"},{"key":"e_1_2_4_12_2","first-page":"594","article-title":"Severe erythema multiforme during terbinafine therapy","volume":"50","author":"Tramaloni S","year":"1995","journal-title":"Therapie"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08573.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1468-3083.2003.00698.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1468-3083.2003.00698.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T19:59:52Z","timestamp":1695844792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1468-3083.2003.00698.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,24]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1046\/j.1468-3083.2003.00698.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1468-3083.2003.00698.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,24]]}}}