{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:33:18Z","timestamp":1791307998730,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,12,23]],"date-time":"2002-12-23T00:00:00Z","timestamp":1040601600000},"content-version":"vor","delay-in-days":1087,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>Objective\u2002To assess the value of uterine artery Doppler ultrasound screening, when performed in a clinical setting, to predict complications of impaired uteroplacental blood flow in high\u2010risk women.<\/jats:p><jats:p>Design\u2002A prospective audit.<\/jats:p><jats:p>Subjects\u2002A total of 116 pregnancies in 114 women at high risk of pre\u2010eclampsia and\/or small\u2010for\u2010gestational\u2010age (SGA) babies attending a maternal\u2013fetal medicine clinic at National Women\u2019s Hospital, a tertiary referral hospital, Auckland, New Zealand.<\/jats:p><jats:p>Methods\u2002Uterine artery Doppler screening was performed as part of clinical practice between 22 and 24\u2003weeks\u2019 gestation. A resistance index (RI) was calculated from each uterine artery and the presence or absence of a notch was determined. An RI of &gt;\u200a0.58 was defined as abnormal and an RI of \u2265\u200a0.7 was defined as very abnormal. The main outcome measures were: pre\u2010eclampsia, SGA baby (birth weight &lt;\u200a10th centile), placental abruption, intrauterine death, \u2018all\u2019 and \u2018severe\u2019 outcomes.<\/jats:p><jats:p>Results\u2002Thirty\u2010two (27.5%) women developed pre\u2010eclampsia, 31 (26.7%) had SGA babies, 23 (20%) were delivered at &lt;\u200a34\u2003weeks because of pregnancy complications, and there were three (2.6%) placental abruptions and three (2.6%) perinatal deaths. The sensitivity of any RI of &gt;\u200a0.58 for pre\u2010eclampsia, SGA, \u2018all\u2019 outcomes and \u2018severe\u2019 outcome was 91%, 84%, 83% and 90%, respectively. The specificity of any RI of &gt;\u200a0.58 for these outcomes was 42%, 39%, 47% and 38%, respectively. The positive predictive value of any RI of &gt;\u200a0.58 for the same outcomes was 37%, 33%, 58% and 24%, respectively. Among women with both RI values of \u2265\u200a0.7, 58%, 67%, 85% and 58% developed pre\u2010eclampsia, SGA, \u2018all\u2019 and \u2018severe\u2019 outcomes, respectively. In women with bilateral notches, 47%, 53%, 76% and 65% developed the respective outcomes. Women with both RI values of \u2265\u200a0.7 and women with bilateral notches had relative risks of 11.1 (95% CI 2.6\u201346.4) and 12.7 (95% CI 4.0\u201340.4) for developing severe outcome, respectively. Only 5% of women with both RI values of &lt;\u200a0.58 developed a severe outcome.<\/jats:p><jats:p>Conclusion\u2002In high\u2010risk women, uterine artery Doppler waveform analysis performed best in the prediction of severe adverse outcome and was better than clinical risk assessment in the prediction of pre\u2010eclampsia and SGA babies. Further studies are necessary to determine how information from uterine artery Doppler studies should modify current practice in high\u2010risk women.<\/jats:p>","DOI":"10.1046\/j.1469-0705.2000.00014.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T23:11:48Z","timestamp":1047510708000},"page":"7-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Mid\u2010trimester uterine artery Doppler screening as a predictor of adverse pregnancy outcome in high\u2010risk women"],"prefix":"10.1002","volume":"15","author":[{"given":"M.A.G.","family":"Coleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.M.E.","family":"McCowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"North","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,12,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91970-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1992.20.2.139"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07830.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90832-R"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90462-X"},{"key":"e_1_2_6_7_2","first-page":"277","article-title":"Systolic or diastolic notch in uterine artery blood flow velocity waveforms in hypertensive pregnant patients: relationship to outcome","volume":"80","author":"Thaler I","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000263700"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.7863\/jum.1992.11.6.275","article-title":"Uterine\u2013umbilical artery Doppler velocimetry in pregnant women with systemic lupus erythematosus","volume":"1","author":"Guzman E","year":"1992","journal-title":"J Ultrasound Med"},{"key":"e_1_2_6_10_2","first-page":"970","article-title":"Pregnancy outcome in relation to uterine artery flow velocity waveforms and clinical characteristics in women with antiphospholipid syndrome","volume":"82","author":"Caruso A","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1996.24.2.141"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb13508.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15139.x"},{"key":"e_1_2_6_14_2","first-page":"378","article-title":"Uterine artery Doppler flow velocity waveforms in the second trimester for the prediction of pre\u2010eclampsia and fetal growth retardation","volume":"83","author":"North RA","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_15_2","first-page":"78","article-title":"Improved prediction of pre\u2010eclampsia by two\u2010stage screening of uterine arteries using the early diastolic notch and color Doppler imaging","volume":"82","author":"Bower S","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07030182.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09549.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1994.22.s1.69"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1994.tb01037.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09662.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803123381101"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09829.x"}],"container-title":["Ultrasound in Obstetrics &amp; 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