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Maximum inhibition resulted in a 50% decrease in forskolin\u2010stimulated activity, consistent with the presence of multiple isoforms of adenylyl cyclase and our previous findings that only the forskolin\u2010stimulated activity of the type\u20105 and \u20106 isoform family of enzymes is inhibited by NO. To monitor primarily the type\u20105 isoform, we examined the ability of NO donors to attenuate D<jats:sub>1<\/jats:sub>\u2010agonist\u2010stimulated adenylyl cyclase activity. Under those\u00a0conditions, complete inhibition was observed. 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