{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:37:07Z","timestamp":1784709427057,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,5,21]],"date-time":"2002-05-21T00:00:00Z","timestamp":1021939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Positron emission tomography (PET) studies have indicated that the<jats:italic>in vivo<\/jats:italic>availability of dopamine D<jats:sub>2<\/jats:sub>\u2010like receptors declines with age in the human brain. Most of the studies have been carried out with healthy male subjects, or with subject groups containing both sexes. The authors have recently demonstrated that the availability of D<jats:sub>2<\/jats:sub>\u2010like receptors in the frontal cortex is higher in women than in men. The present study was aimed to further examine this phenomenon. Thirty\u2010seven healthy women (age range 22\u201378\u2003years) were examined with PET and [<jats:sup>11<\/jats:sup>C]FLB 457, a high\u2010affinity tracer for the extrastriatal D<jats:sub>2<\/jats:sub>\u2010like receptors. A negative relationship between age and dopamine D<jats:sub>2<\/jats:sub>\u2010like receptor availability was seen in the frontal cortex (decrease of 12% per decade of life), the temporal cortex (9%) and the thalamus (6%). A non\u2010linear s\u2010shape association explained the relationship only in the frontal cortex, while in other regions the association was linear. Neither oestradiol nor progesterone levels had a significant relationship with the [<jats:sup>11<\/jats:sup>C]FLB 457 uptake in any of the brain regions studied after the effect of age was partialled out. The results indicate that: (i) the extrastriatal D<jats:sub>2<\/jats:sub>\u2010like receptor availability decreases with age in healthy women with the fastest rate in the frontal cortex and with the overall rate close to the rate reported in healthy men; (ii) around midlife (age 40\u201360\u2003years) in women, the frontal receptor decline plateaus while the decline continues to be linear in other extrastriatal brain regions; and (iii) serum oestradiol or progesterone levels are not associated with cortical or thalamic D<jats:sub>2<\/jats:sub>\u2010like receptor availability in women. The results may prove to be important in studies where the biochemical basis of clinical sex differences is examined in patients with dopamine\u2010related neuropsychiatric disorders.<\/jats:p>","DOI":"10.1046\/j.1471-4159.2002.00895.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T07:00:47Z","timestamp":1047452447000},"page":"1005-1010","source":"Crossref","is-referenced-by-count":46,"title":["Age\u2010related loss of extrastriatal dopamine D<sub>2<\/sub>\u2010like receptors in women"],"prefix":"10.1111","volume":"81","author":[{"given":"Valtteri","family":"Kaasinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Kemppainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"N\u00e5gren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Helenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Kurki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha O.","family":"Rinne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,5,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540050026010"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.1994.5.1.27"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199909000-00010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/385590a0"},{"key":"e_1_2_5_6_1","first-page":"1275","article-title":"Carbon\u201011\u2010FLB 457: a radioligand for extrastriatal D2 dopamine receptors","volume":"36","author":"Halldin C.","year":"1995","journal-title":"J. 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