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Because Alzheimer's disease impairs memory, and infusion of amyloid\u2010\u03b2 (A\u03b2) peptide (1\u201340) into the rat cerebral ventricle reduces learning ability, we investigated the effect of dietary pre\u2010administration of docosahexaenoic acid on avoidance learning ability in A\u03b2 peptide\u2010produced Alzheimer's disease model rats. After a mini\u2010osmotic pump filled with A\u03b2 peptide or vehicle was implanted in docosahexaenoic acid\u2010fed and control rats, they were subjected to an active avoidance task in a shuttle avoidance system apparatus. Pre\u2010administration of docosahexaenoic acid had a profoundly beneficial effect on the decline in avoidance learning ability in the Alzheimer's disease model rats, associated with an increase in the cortico\u2010hippocampal docosahexaenoic acid\/arachidonic acid molar ratio, and a decrease in neuronal apoptotic products. Docosahexaenoic acid pre\u2010administration furthermore increased cortico\u2010hippocampal reduced glutathione levels and glutathione reductase activity, and suppressed the increase in lipid peroxide and reactive oxygen species levels in the cerebral cortex and hippocampus of the Alzheimer's disease model rats, suggesting an increase in antioxidative defence. Docosahexaenoic acid is thus a possible prophylactic means for preventing the learning deficiencies of Alzheimer's disease.<\/jats:p>","DOI":"10.1046\/j.1471-4159.2002.00905.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T07:00:47Z","timestamp":1047452447000},"page":"1084-1091","source":"Crossref","is-referenced-by-count":306,"title":["Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats"],"prefix":"10.1111","volume":"81","author":[{"given":"Michio","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahdat","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Sugioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Ichiro","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Shido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,5,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"H379","article-title":"Differential effects of dietary fish oil on myocardial prostaglandin I2 and thromboxane A2 production","volume":"260","author":"Abeywardena M. 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