{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:42Z","timestamp":1791405222479,"version":"4.3.3"},"reference-count":52,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":6271,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[1998,10]]},"DOI":"10.1046\/j.1523-1747.1998.00334.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:47:09Z","timestamp":1047448029000},"page":"621-628","source":"Crossref","is-referenced-by-count":143,"title":["Patients with Allergic Contact Dermatitis to Nickel and Nonallergic Individuals Display Different Nickel-Specific T Cell Responses. Evidence for the Presence of Effector CD8+ and Regulatory CD4+ T Cells"],"prefix":"10.1016","volume":"111","author":[{"given":"Andrea","family":"Cavani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Corinti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Giani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Pirrotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Puddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0010","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/1523-1747.ep12289700","article-title":"Cytokine gene expression during the elicitation phase of contact sensitivity: regulation by endogenous IL-4","volume":"108","author":"Asada","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0015","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/eji.1830270214","article-title":"High and low dose of haptens dictate whether dermal or epidermal antigen-presenting cells promote contact hypersensitivity","volume":"27","author":"Bacci","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0020","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/intimm\/4.12.1389","article-title":"Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures","volume":"12","author":"Bejarano","year":"1992","journal-title":"Int Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.182.1.99","article-title":"Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses","volume":"182","author":"Berg","year":"1995","journal-title":"J Exp Med"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0030","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/1523-1747.ep12469023","article-title":"In vitro studies in nickel allergy: diagnostic value of a dual parameter analysis","volume":"88","author":"von Blomberg-van der Fliers","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00372006","article-title":"Skin-homing T lymphocytes: detection of cutaneous lymphocyte-associated antigen (CLA) by HECA-452 in normal human skin","volume":"285","author":"Bos","year":"1993","journal-title":"Arch Dermatol Res"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0040","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1002\/eji.1830251103","article-title":"Major histocompatibility complex class I-restricted CD8 + T cells and class II-restricted CD4+ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene","volume":"25","author":"Bour","year":"1995","journal-title":"Eur J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0045","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1398-9995.1988.tb00409.x","article-title":"Lymphocyte proliferative response to the purified Dermatophagoides farinae major allergen in untreated and hyposensitized atopic patients","volume":"43","author":"Cavaillon","year":"1988","journal-title":"Allergy"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0050","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4049\/jimmunol.154.3.1232","article-title":"Characterization of epitopes recognized by hapten-specific CD4+ T cells","volume":"154","author":"Cavani","year":"1995","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0055","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.4049\/jimmunol.144.7.2486","article-title":"Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity","volume":"144","author":"Cruz","year":"1989","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0060","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1084\/jem.178.3.1041","article-title":"Interleukin 10 (IL-10) inhibits human lymphocyte interferon \u03b3-production by suppressing natural killer cell stimulatory factor\/IL-12 synthesis in accessory cells","volume":"178","author":"D\u2019andrea","year":"1993","journal-title":"J Exp Med"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0065","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4049\/jimmunol.150.2.353","article-title":"Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production","volume":"150","author":"Del Prete","year":"1993","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0070","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/1523-1747.ep12469732","article-title":"HLA-DR, -DQ, and \u2014DP alleles in nickel, chromium, and\/or cobalt-sensitive individuals: genomic analsys based on restriction fragment length polymorphism","volume":"100","author":"Emtestam","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0075","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.4049\/jimmunol.151.5.2390","article-title":"Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance","volume":"151","author":"Enk","year":"1993","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0080","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1084\/jem.179.4.1397","article-title":"Induction of hapten-specific tolerance by interleukin 10 in vivo","volume":"179","author":"Enk","year":"1994","journal-title":"J Exp Med"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0085","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1084\/jem.179.5.1597","article-title":"Regulation of contact hypersensitivity by interleukin 10","volume":"179","author":"Ferguson","year":"1994","journal-title":"J Exp Med"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0090","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.4049\/jimmunol.146.10.3444","article-title":"IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells","volume":"146","author":"Fiorentino","year":"1991","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0095","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/40166","article-title":"Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells","volume":"389","author":"Fuhlbrigge","year":"1997","journal-title":"Nature"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0100","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.4049\/jimmunol.148.5.1411","article-title":"Anti-inflammatory action of IL-4. Negative regulation of contact sensitivity to trinitrochlorobenzene","volume":"148","author":"Gautam","year":"1992","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0105","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.4049\/jimmunol.150.10.4236","article-title":"Phosphatidylserine enhances the ability of epidermal Langerhans cells to induce contact hypersensitivity","volume":"150","author":"Girolomoni","year":"1993","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0110","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.4049\/jimmunol.144.11.4121","article-title":"Roles of CD4 + and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion","volume":"144","author":"Gocinski","year":"1990","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0115","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1001\/archderm.1993.01680280064012","article-title":"Idiopathic CD4+ lymphocyte deficiency","volume":"129","author":"Goodrich","year":"1993","journal-title":"Arch Dermatol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-5699(97)01186-9","article-title":"Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity","volume":"19","author":"Grabbe","year":"1998","journal-title":"Immunol Today"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0125","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/39614","article-title":"A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis","volume":"389","author":"Groux","year":"1997","journal-title":"Nature"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0130","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1182\/blood.V88.9.3513.bloodjournal8893513","article-title":"Heterogeneity of the human CD4 + T cell subsets characterized by coexpression of CD45 RA and CD45RO isoforms","volume":"88","author":"Hamann","year":"1996","journal-title":"Blood"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0135","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/1523-1747.ep12555587","article-title":"Cultured epidermal Langerhans cells activate effector T cells for contact sensitivity","volume":"95","author":"Hauser","year":"1990","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0140","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.8097338","article-title":"Development of Th1, CD4+ T cells through IL-12 produced by Listeria-induced macrophages","volume":"260","author":"Hsieh","year":"1993","journal-title":"Science"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0145","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.4049\/jimmunol.145.11.3706","article-title":"Enrichment and function of urushiol (poison ivy) -specific T lymphocytes in lesions of allergic contact dermatitis to urushiol","volume":"145","author":"Kalish","year":"1990","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0150","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/eji.1830170620","article-title":"Nickel-specific T lymphocyte clones derived from allergic nickel-contact dermatitis lesions in man: heterogeneity based on requirement of dendritic antigen-presenting cell subsets","volume":"17","author":"Kapsenberg","year":"1987","journal-title":"Eur J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0155","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/1523-1747.ep12494841","article-title":"Th1 lymphokine production profiles of nickel-specific CD4+ T-lymphocyte clones from nickel contact allergic and nonallergic individuals","volume":"98","author":"Kapsenberg","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0160","series-title":"Limiting Dilution Analysis of Cells in the Immune System","author":"Lefkovitz","year":"1979"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0165","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.4049\/jimmunol.150.9.3755","article-title":"Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-\u03b3 production","volume":"150","author":"Macatonia","year":"1993","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0170","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.4049\/jimmunol.149.8.2569","article-title":"Role of hapten-anchoring peptides in defining hapten-epitopes for MHC-restricted cytotoxic T-cells: cross-reactive TNP-determinants on different peptides","volume":"149","author":"Martin","year":"1992","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0175","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.4049\/jimmunol.155.10.4661","article-title":"IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo","volume":"155","author":"Muller","year":"1995","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0180","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/1523-1747.ep12280705","article-title":"Non-specific lymphocyte transformation in vitro by nickel acetate","volume":"55","author":"Pappas","year":"1970","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0185","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0536.1979.tb05531.x","article-title":"Nickel sensitivity in the general population","volume":"5","author":"Peltonen","year":"1979","journal-title":"Contact Dermatitis"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0190","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/349796a0","article-title":"ELAM-1 is an adhesion molecule for skin-homing T cells","volume":"349","author":"Picker","year":"1991","journal-title":"Nature"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0195","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1600-0536.1992.tb03255.x","article-title":"Diagnostic value of the lymphocyte proliferation test in nickel contact allergy and provocation in occupational coin dermatitis","volume":"27","author":"R\u00e4s\u00e4nen","year":"1992","journal-title":"Contact Dermatitis"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0200","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.4049\/jimmunol.156.5.1799","article-title":"Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten-specific tolerance","volume":"156","author":"Riemann","year":"1996","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0205","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.4049\/jimmunol.146.4.1175","article-title":"Cyclic regulation of CD45 isoform expression in a long term human CD4 +CD45RA+ T cell line","volume":"146","author":"Rothstein","year":"1991","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0210","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1398-9995.1993.tb02172.x","article-title":"T-cell and antibody response to Parietaria judaica allergenic fractions in atopic and nonatopic individuals","volume":"48","author":"Sallusto","year":"1993","journal-title":"Allergy"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0215","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1084\/jem.181.5.1935","article-title":"Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen","volume":"181","author":"Santamaria Babi","year":"1995","journal-title":"J Exp Med"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0220","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-0536.1996.tb02136.x","article-title":"Pre-treatment of nickel test areas with sodium lauryl sulfate detects nickel sensitivity in subjects reacting negatively to routinely performed patch tests","volume":"34","author":"Seidenari","year":"1996","journal-title":"Contact Dermatitis"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0225","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.4049\/jimmunol.135.6.3929","article-title":"Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis","volume":"135","author":"Sinigaglia","year":"1985","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0230","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2340\/0001555558245250","article-title":"Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test","volume":"58","author":"Svejgaard","year":"1978","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0235","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-2133.1997.18051888.x","article-title":"Atopic and nonatopic individuals react to nickel challenge in a similar way. A study of the cytokine profile in nickel-induced contact dermatitis","volume":"137","author":"Szepietowski","year":"1997","journal-title":"Br J Dermatol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0240","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1600-0536.1994.tb02033.x","article-title":"Allergic contact dermatitis in HIV-positive patients","volume":"31","author":"Viraben","year":"1994","journal-title":"Contact Dermatitis"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0245","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1002\/eji.1830270808","article-title":"Dominance of the BV17 element in nickel-specific human T cell receptors relates to severity of contact sensitivity","volume":"27","author":"Vollmer","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0250","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1046\/j.1365-3083.1997.d01-402.x","article-title":"Diminished contact hypersensitivity response in IL-4 deficient mice at a late phase of the elicitation reaction","volume":"45","author":"Weigmann","year":"1997","journal-title":"Scand J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0255","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.4049\/jimmunol.158.5.2500","article-title":"Dichotomy of blood- and skin-derived IL-4-producing allergen-specific T cells and restricted V\u03b2 repertoire in nickel-mediated contact dermatitis","volume":"158","author":"Werfel","year":"1997","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0260","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.4049\/jimmunol.147.9.2942","article-title":"Human atopen-specific types 1 and 2 helper cell clones","volume":"147","author":"Wierenga","year":"1991","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.1998.00334.x_bb0265","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.183.3.1001","volume":"183","author":"Xu","year":"1996","journal-title":"J Exp Med"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15402350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15402350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T15:36:35Z","timestamp":1704296195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15402350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["S0022202X15402350"],"URL":"https:\/\/doi.org\/10.1046\/j.1523-1747.1998.00334.x","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}