{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:42:19Z","timestamp":1791495739958,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":5662,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1046\/j.1523-1747.2000.00985.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T05:53:48Z","timestamp":1047448428000},"page":"1164-1173","source":"Crossref","is-referenced-by-count":129,"title":["A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfonamide-Induced Cutaneous Drug Reactions"],"prefix":"10.1016","volume":"114","author":[{"given":"Timothy P.","family":"Reilly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence H.","family":"Lash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Doll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Hein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Woster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig K.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0010","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1182\/blood.V86.1.258.bloodjournal861258","article-title":"Increased levels of oxidized glutathione in CD4+ lymphocytes associated with disturbed intracellular redox balance in human immunodeficiency virus type 1 infection","volume":"86","author":"Aukrust","year":"1995","journal-title":"Blood"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0015","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0140-6736(89)91909-0","article-title":"Systemic glutathione deficiency in symptom-free HIV-seropositive individuals","volume":"2","author":"Buhl","year":"1989","journal-title":"Lancet"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0020","series-title":"AIDS Clin Rev","first-page":"65","article-title":"Pathogenesis and management of HIV-associated drug hypersensitivity","author":"Carr","year":"1995"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0025","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1365-2249.1994.tb06078.x","article-title":"Immunohistological assessment of cutaneous drug hypersensitivity in patients with HIV infection","volume":"97","author":"Carr","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0030","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1365-2125.1989.tb03517.x","article-title":"Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes","volume":"28","author":"Coleman","year":"1989","journal-title":"Br J Clin Pharmacol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0035","first-page":"9","article-title":"Adverse reactions to sulphonamide and sulphonamide-trimethoprim antimicrobials: clinical syndromes and pathogenesis","volume":"15","author":"Cribb","year":"1996","journal-title":"Adverse Drug React Toxicol Rev"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0040","first-page":"900","article-title":"Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity","volume":"19","author":"Cribb","year":"1991","journal-title":"Drug Metab Dispos"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0045","first-page":"744","article-title":"Peroxidase-dependent oxidation of sulfonamides by monocytes and neutrophils from humans and dogs","volume":"38","author":"Cribb","year":"1990","journal-title":"Mol Pharmacol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0050","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/0006-2952(93)90280-A","article-title":"Role of polymorphic and monomorphic human arylamine N-acetyltransferases in determining sulfamethoxazole metabolism","volume":"45","author":"Cribb","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0055","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1021\/tx950167j","article-title":"Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection","volume":"9","author":"Cribb","year":"1996","journal-title":"Chem Res Toxicol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0060","first-page":"406","article-title":"N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes","volume":"23","author":"Cribb","year":"1995","journal-title":"Drug Metab Dispos"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0065","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.4049\/jimmunol.152.4.1546","article-title":"Heat shock enhances antigen processing and accelerates the formation of compact class II \u03b1\u03b2 dimers","volume":"152","author":"Cristau","year":"1994","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0070","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1365-2567.1997.00360.x","article-title":"Langerhans' cells require signals from both tumor necrosis factor-\u03b1 and interleukin-1\u03b2 for migration","volume":"92","author":"Cumberbatch","year":"1997","journal-title":"Immunol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0075","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1046\/j.1365-2133.1999.02964.x","article-title":"Tumour necrosis factor-alpha induced Langerhans' cell migration in humans","volume":"141","author":"Cumberbatch","year":"1999","journal-title":"Br J Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0080","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0076-6879(87)43018-8","article-title":"High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives","volume":"143","author":"Fariss","year":"1987","journal-title":"Meth Enzymol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0085","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.4049\/jimmunol.141.7.2216","article-title":"Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific TH1 clones","volume":"141","author":"Gaspari","year":"1988","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0090","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1021\/tx980001t","article-title":"Procainamide, a drug causing lupus, induces prostaglandin H synthase-2 and formation of T cell-sensitizing drug metabolites in mouse macrophages","volume":"12","author":"Goebel","year":"1999","journal-title":"Chem Res Toxicol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0095","doi-asserted-by":"crossref","first-page":"495","DOI":"10.7326\/0003-4819-100-4-495","article-title":"Adverse reactions to trimethoprim-sulfamethoxazole in patients with acquired immunodeficiency syndrome","volume":"100","author":"Gordin","year":"1984","journal-title":"Ann Intern Med"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0100","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1126\/science.1828619","article-title":"Recognition of self antigens by skin-derived T cells with invariant gamma-delta antigen receptors","volume":"252","author":"Havran","year":"1991","journal-title":"Science"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0105","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1046\/j.1365-2133.1998.2576o.x","article-title":"Bullous fixed drug eruption due to paracetamol with an unusual immunofluorescence","volume":"139","author":"Hern","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0110","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/1523-1747.ep12371697","article-title":"Predominance of epidermal CD8+ T lymphocytes in bullous cutaneous reactions caused by \u03b2-lactam antibiotics","volume":"101","author":"Hertl","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0115","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1365-2133.1995.tb05016.x","article-title":"CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes","volume":"132","author":"Hertl","year":"1995","journal-title":"Br J Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0120","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1073\/pnas.94.5.1967","article-title":"Glutathione deficiency is associated with impaired survival in HIV disease","volume":"94","author":"Herzenberg","year":"1997","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0125","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.4049\/jimmunol.155.6.2888","article-title":"Activation of murine epidermal TCR-\u03b3\u03b4+ T cells by keratinocytes treated with contact sensitizers","volume":"155","author":"Huber","year":"1995","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0130","series-title":"Lancet","first-page":"1109","article-title":"Complications of co-trimoxazole in treatment of AIDS-associated Pneumocystis carinii pneumonia in homosexual men","author":"Jaffe","year":"1983"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0135","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1523-1747.1998.00340.x","article-title":"Cholecalciferol induces prostaglandin E2 biosynthesis and transglutaminase activity in human keratinocytes","volume":"111","author":"Kanekura","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0140","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3109\/03602539009041089","article-title":"Cutaneous metabolism of xenobiotics","volume":"22","author":"Kao","year":"1990","journal-title":"Drug Metab Rev"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0022-1759(84)90219-9","article-title":"An enzyme-linked immunosorbent assay for detection of antibodies against halothane-altered hepatocyte antigens","volume":"75","author":"Kenna","year":"1984","journal-title":"J Immunol Method"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0150","doi-asserted-by":"crossref","first-page":"663","DOI":"10.7326\/0003-4819-100-5-663","article-title":"Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies","volume":"100","author":"Kovaks","year":"1984","journal-title":"Ann Intern Med"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0155","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/smim.1998.0143","article-title":"An innate sense of danger","volume":"10","author":"Matzinger","year":"1998","journal-title":"Sem Immunol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0160","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1056\/NEJM199009203231202","article-title":"Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a controlled trial of trimethoprim-sulfamethoxazole vs. trimethoprim-dapsone","volume":"323","author":"Medina","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0165","series-title":"Dermatotoxicology","first-page":"61","article-title":"Biotransformations in the skin","author":"Merk","year":"1996"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0170","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/archderm.1991.01680050095011","article-title":"T-cell subsets in drug-induced toxic epidermal necrolysis. Possible pathogenic mechanism induced by CD8-positive T cells","volume":"127","author":"Miyauchi","year":"1991","journal-title":"Arch Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0175","first-page":"1099","article-title":"In vitro formation, disposition and toxicity of N-acetoxy-sulfamethoxazole, a potential mediator of sulfamethoxazole toxicity","volume":"274","author":"Nakamura","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0180","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1046\/j.1365-2133.1998.02214.x","article-title":"Antigen-presenting cell function of epidermal cells activated by hapten application","volume":"138","author":"Nakano","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0185","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1001\/archderm.1991.01680050115015","article-title":"The cytokine network in psoriasis","volume":"127","author":"Nickoloff","year":"1991","journal-title":"Arch Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0190","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/1523-1747.ep12523513","article-title":"Human keratinocyte-lymphocyte-reactions in vitro","volume":"87","author":"Nickoloff","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0195","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.4049\/jimmunol.150.6.2148","article-title":"Accessory cell function of keratinocytes for superantigens: dependence on lymphocyte function-associated antigen-1\/intracellular adhesion molecule-1 interaction","volume":"150","author":"Nickoloff","year":"1993","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0200","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/13547509609079367","article-title":"Further investigations of the role of acetylation in sulphonamide hypersensitivity reactions","volume":"1","author":"Nuss","year":"1996","journal-title":"Biomarkers"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0205","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1346-8138.1994.tb01405.x","article-title":"Immunochemical study of graft-versus-host reaction (GVHR) -type drug eruptions","volume":"21","author":"Osawa","year":"1994","journal-title":"J Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0210","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1021\/tx980058f","article-title":"Role of drug disposition in drug hypersensitivity: a chemical, molecular, and clinical perspective","volume":"11","author":"Park","year":"1998","journal-title":"Chem Res Toxicol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0215","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1365-2133.1996.tb06976.x","article-title":"Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis","volume":"134","author":"Paul","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0220","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.pa.28.040188.002055","article-title":"The immunologic and metabolic basis of drug hypersensitivities","volume":"28","author":"Pohl","year":"1988","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0225","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S0140-6736(67)91893-4","article-title":"Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis","volume":"2","author":"Pullen","year":"1967","journal-title":"Lancet"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0230","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0006-2952(97)00547-9","article-title":"Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone","volume":"55","author":"Reilly","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0235","first-page":"1356","article-title":"Is hydroxylamine-induced cytotoxicity a valid marker for hypersensitivity reactions to sulfamethoxazole in HIV-infected individuals?","volume":"291","author":"Reilly","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0240","first-page":"724","article-title":"Synthesis and in vitro toxicity of hydroxylamine metabolites of sulfonamides","volume":"244","author":"Rieder","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0245","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1046\/j.1365-2222.1998.00419.x","article-title":"T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazole-induced skin reaction","volume":"28","author":"Schnyder","year":"1998","journal-title":"Clin Exp Allerg"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0250","series-title":"Idiosyncratic Adverse Drug Reactions","first-page":"99","article-title":"The skin as a target organ for adverse drug reactions","author":"Shear","year":"1990"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0255","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1001\/archderm.1989.01670220067010","article-title":"Fixed drug eruption. Expression of epidermal keratinocyte intercellular adhesion molecule-1 (ICAM-1)","volume":"125","author":"Shiohara","year":"1989","journal-title":"Arch Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0260","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/0140-6736(92)90939-Z","article-title":"Glutathione deficiency and human immunodeficiency virus infection","volume":"339","author":"Staal","year":"1992","journal-title":"Lancet"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0265","series-title":"The Keratinocyte Handbook","first-page":"365","article-title":"Keratinocytes and immunological cytokines","author":"Stoof","year":"1994"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0270","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1006\/faat.1997.2316","article-title":"A rapid in vitro assay for evaluation of metabolism-dependent cytotoxicity of antiepileptic drugs on isolated human lymphocytes","volume":"37","author":"Tabatabaei","year":"1997","journal-title":"Fundam Appl Toxicol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0275","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/tx980249i","article-title":"New concepts in immunology relevant to idiosyncratic drug reactions: the \u2018Danger Hypothesis' and innate immune system","volume":"12","author":"Uetrecht","year":"1999","journal-title":"Chem Res Toxicol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0280","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3109\/03602539208996297","article-title":"The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions","volume":"24","author":"Uetrecht","year":"1992","journal-title":"Drug Metab Rev"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0285","first-page":"830","article-title":"N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system","volume":"21","author":"Uetrecht","year":"1993","journal-title":"Drug Metab Dispos"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0290","first-page":"274","article-title":"Metabolism of dapsone to a hydroxylamine by human neutrophils and mononuclear cells","volume":"245","author":"Uetrecht","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0295","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/taap.1994.1255","article-title":"Dapsone-induced hematologic toxicity: comparison of the methemoglobin-forming ability of hydroxylamine metabolites of dapsone in rat and human blood","volume":"129","author":"Vage","year":"1994","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0300","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1001\/archderm.1992.01680110060006","article-title":"Immunopathology of toxic epidermal necrolysis. Keratinocytes, HLA-DR expression, Langerhans cells, and mononuclear cells: an immunological study of five cases","volume":"128","author":"Villada","year":"1992","journal-title":"Arch Dermatol"},{"key":"10.1046\/j.1523-1747.2000.00985.x_bb0305","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/intimm\/10.5.609","article-title":"Hsp72-mediated augmentation of MHC class I surface expression and endogenous antigen presentation","volume":"10","author":"Wells","year":"1998","journal-title":"Int Immunol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1540898X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1540898X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T17:47:18Z","timestamp":1682099238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X1540898X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0022202X1540898X"],"URL":"https:\/\/doi.org\/10.1046\/j.1523-1747.2000.00985.x","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}