{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:53:47Z","timestamp":1791888827214,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":4963,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1046\/j.1523-1747.2002.01751.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T06:02:59Z","timestamp":1047448979000},"page":"845-850","source":"Crossref","is-referenced-by-count":176,"title":["Staphylococcal Exfoliative Toxin B Specifically Cleaves Desmoglein 1"],"prefix":"10.1016","volume":"118","author":[{"given":"Masayuki","family":"Amagai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nishifuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Hanakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Sugai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0010","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1046\/j.1365-2133.1999.02721.x","article-title":"Staphylococcal scalded skin syndrome in an adult associated with methicillin-resitant Staphylococcus aureus","volume":"140","author":"Acland","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0923-1811(99)00016-X","article-title":"Autoimmunity against desmosomal cadherins in pemphigus","volume":"20","author":"Amagai","year":"1999","journal-title":"J Dermatol Sci"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0020","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/1523-1747.ep12606168","article-title":"Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus","volume":"104","author":"Amagai","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0025","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/81385","article-title":"Toxin in bullous impetigo and staphylococcal scalded skin syndrome targets desmoglein 1","volume":"6","author":"Amagai","year":"2000","journal-title":"Nature Med"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0030","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1073\/pnas.86.22.8941","article-title":"Interaction of Staphylococcus aureus toxin \u2018superantigens\u2019 with human T cells","volume":"86","author":"Choi","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0035","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1083\/jcb.113.2.381","article-title":"Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains","volume":"113","author":"Collins","year":"1991","journal-title":"J Cell Biol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0190-9622(94)70032-X","article-title":"Staphylococcal scalded skin syndrome in adults: a clinical review illustrated with a new case","volume":"30","author":"Cribier","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0045","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-5793(90)80990-Z","article-title":"The epidermolytic toxins are serine proteases","volume":"268","author":"Dancer","year":"1990","journal-title":"FEBS Lett"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0050","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2133.1977.tb07150.x","article-title":"The staphylococcal scalded skin syndrome: an experimental histochemical and electron microscopic study","volume":"96","author":"Dimond","year":"1977","journal-title":"Br J Dermatol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0055","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/1523-1747.ep12610196","article-title":"Staphylococcal toxic epidermal necrolysis: pathogenesis and studies on the subcellular site of action of exfoliatin","volume":"65","author":"Elias","year":"1975","journal-title":"J Invest Dermatol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0060","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00191548","article-title":"Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen","volume":"180","author":"Fleischer","year":"1992","journal-title":"Med Microbiol Immunol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00216783","article-title":"Superantigens and pseudosuperantigens of gram-positive cocci","volume":"184","author":"Fleischer","year":"1995","journal-title":"Med Microbiol Immunol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0070","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1099\/00222615-43-5-318","article-title":"Staphylococcal scalded skin syndrome","volume":"43","author":"Gemell","year":"1995","journal-title":"J Med Microbiol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0075","series-title":"Gram-positive pathogens","first-page":"317","article-title":"Genetic and physical map of the chromosome of Staphylococcus aureus 8325","author":"Iandolo","year":"2000"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0080","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.4049\/jimmunol.159.4.2010","article-title":"Characterization of autoantibodies in pemphigus using antigen-specific ELISAs with baculovirus expressed recombinant desmogleins","volume":"159","author":"Ishii","year":"1997","journal-title":"J Immunol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0085","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1128\/jb.167.2.726-728.1986","article-title":"Sequence of the exfoliative toxin B gene of Staphylococcus aureus","volume":"167","author":"Jackson","year":"1986","journal-title":"J Bacteriol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0090","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.2524876","article-title":"V beta-specific stimulation of human T cells by staphylococcal toxins","volume":"244","author":"Kappler","year":"1989","journal-title":"Science"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0095","first-page":"1","article-title":"Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules","volume":"53","author":"Koch","year":"1990","journal-title":"Eur J Cell Biol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0100","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/CMR.12.2.224","article-title":"Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome","volume":"12","author":"Ladhani","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0105","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1128\/jb.169.9.3904-3909.1987","article-title":"Sequence determination and comparison of the exfoliative toxin A and toxin B genes from Staphylococcus aureus","volume":"169","author":"Lee","year":"1987","journal-title":"J Bacteriol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0110","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1542\/peds.50.5.728","article-title":"Site of action of exfoliative toxin in the staphylococcal scaled-skin syndrome","volume":"50","author":"Lillibridge","year":"1972","journal-title":"Pediatrics"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0115","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1172\/JCI5252","article-title":"Explanation for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris","volume":"103","author":"Mahoney","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0120","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1056\/NEJM197005142822002","article-title":"The staphylococcal scalded skin syndrome: development of an experimental model","volume":"282","author":"Melish","year":"1970","journal-title":"N Engl J Med"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0125","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/infdis\/125.2.129","article-title":"The staphylococcal scalded-skin syndrome. Isolation and partial characterization of the exfoliative toxin","volume":"125","author":"Melish","year":"1972","journal-title":"J Infect Dis"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1749-6632.1974.tb41501.x","article-title":"The staphylococcal epidermolytic toxin: its isolation, characterization, and site of action","volume":"236","author":"Melish","year":"1974","journal-title":"Ann NY Acad Sci"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0135","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1073\/pnas.93.3.1320","article-title":"Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome","volume":"93","author":"Miyake","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0140","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/00006454-198805000-00003","article-title":"Microbiologic characteristics of exfoliative toxin-producing Staphylococcus aureus","volume":"7","author":"Murono","year":"1988","journal-title":"Pediatr Infect Dis J"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0145","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0882-4010(86)90043-4","article-title":"Molecular cloning and expression of the epidermolytic toxin A gene of Staphylococcus aureus","volume":"1","author":"O'Toole","year":"1986","journal-title":"Microb Pathog"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0150","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-2133.2000.03328.x","article-title":"Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris","volume":"142","author":"Proby","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0155","first-page":"85","article-title":"A possible receptor substance for staphylococcal exfoliatin isolated from mice","volume":"32","author":"Sakurai","year":"1979","journal-title":"Jpn J Med Sci Biol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0160","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1247\/csf.11.245","article-title":"N-linked oligosaccharides are not involved in the function of a cell-cell binding glycoprotein E-cadherin","volume":"11","author":"Shirayoshi","year":"1986","journal-title":"Cell Struct Funct"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0165","first-page":"341","article-title":"Epidermolytic toxin binds to components in the epidermis of a resistant species","volume":"49","author":"Smith","year":"1989","journal-title":"Eur J Cell Biol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0170","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0065-2776(08)60503-9","article-title":"Cell adhesion molecules as targets of autoantibodies in pemphigus and pemphigoid, bullous diseases due to defective epidermal cell adhesion","volume":"53","author":"Stanley","year":"1993","journal-title":"Adv Immunol"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0175","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-1119(98)00508-3","article-title":"Identification and molecular characterization of a gene homologous to epr (endopeptidase resistance gene) in Staphylococcus aureus","volume":"224","author":"Sugai","year":"1998","journal-title":"Gene"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0180","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1128\/IAI.63.4.1591-1594.1995","article-title":"Possible receptor for exfoliative toxins produced by Staphylococcus hyicus and Staphylococcus aureus","volume":"63","author":"Tanabe","year":"1995","journal-title":"Infect Immun"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0185","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1021\/bi962614f","article-title":"The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease","volume":"36","author":"Vath","year":"1997","journal-title":"Biochemistry"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0190","doi-asserted-by":"crossref","first-page":"10239","DOI":"10.1021\/bi990721e","article-title":"The crystal structure of exfoliative toxin B: a superantigen with enzymatic activity","volume":"38","author":"Vath","year":"1999","journal-title":"Biochemistry"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0195","doi-asserted-by":"crossref","first-page":"7760","DOI":"10.1128\/IAI.69.12.7760-7771.2001","article-title":"Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C","volume":"69","author":"Yamaguchi","year":"2001","journal-title":"Infect Immun"},{"key":"10.1046\/j.1523-1747.2002.01751.x_bb0200","first-page":"722","article-title":"Staphylococcal scalded skin syndrome caused by exfoliative toxin B-producing methicillin-resistant Staphylococcus aureus","volume":"155","author":"Yokota","year":"1996","journal-title":"Eur J Pediatr"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15416525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15416525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T16:55:56Z","timestamp":1682355356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15416525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0022202X15416525"],"URL":"https:\/\/doi.org\/10.1046\/j.1523-1747.2002.01751.x","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}