{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:51:39Z","timestamp":1753887099140},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":1395,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:sec><jats:title>Background.<\/jats:title><jats:p>A follow\u2010up of argyrophil cell hyperplasia in <jats:italic>Helicobacter pylori<\/jats:italic>\u2010positive corpus gastritis in gastric ulcer patients during the natural course of ulcer disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Endoscopic biopsies (4 specimens) were obtained step\u2010wise from the posterior wall of the corpus mucosa in 55 gastric ulcer (GU) patients. The natural course of GU was followed up in 38 patients during more than 10~years (maximum 19~years), and altogether 115 endoscopic examinations were made: 20 patients were re\u2010examined once, 14 twice, and 4 three times. A total of 364 biopsies from 307 biopsy sites were stained by Grimelius\u2019 silver, hematoxylin\u2010eosin, and Giemsa method for the analysis of the argyrophil endocrine cells, chronic gastritis, and <jats:italic>H. pylori<\/jats:italic> colonization, respectively, according to the Sydney System.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Of 307 biopsy sites, 153 (50%) showed some grade of ACH. Focal (linear\/micronodular) hyperplasia was found in 118 (77%) of biopsy sites; it was detected in 78 (66%) cases of atrophic corpus mucosa, but was present in only 14 (12%) cases of gastritis without atrophy or in the normal mucosa. In the follow\u2010up patients, ACH evolved in 17 and progressed in 6 cases, and a simultaneous development of atrophic corpus gastritis was found in 20 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>This study demonstrates that ACH evolves during the natural course of GU, alongside the development of chronic atrophic gastritis.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1523-5378.1998.08038.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T23:20:28Z","timestamp":1047424828000},"page":"39-44","source":"Crossref","is-referenced-by-count":5,"title":["Follow\u2010Up of <i>Helicobacter pylori<\/i> Positive Gastritis and Argyrophil Cells Pattern During the Natural Course of Gastric Ulcer"],"prefix":"10.1111","volume":"3","author":[{"given":"Heidi\u2010Ingrid","family":"Maaroos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niilo","family":"Havu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pentti","family":"Sipponen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"issue":"166","key":"e_1_2_5_2_2","first-page":"19","article-title":"A review of the effects of long\u2010term acid inhibition in animals","volume":"24","author":"Carlsson E.","year":"1989","journal-title":"Gastroenterol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091259"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091260"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90344-C"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90131-3"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000199389"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.4.371"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529109093198"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529109093193"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","unstructured":"Campylobacter pyloriand duodenal ulcer the gastrin link. 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