{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:42:28Z","timestamp":1697521348507},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":1211,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:sec><jats:title>Background.<\/jats:title><jats:p>Acid pump inhibitors combined with antimicrobials cure gastritis and peptic ulcer disease but a standard therapy has not yet been established. We therefore investigated a triple therapy with pantoprazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>The aim of this open\u2010label monocenter trial, involving 30 intention\u2010to\u2010treat patients with peptic ulcer disease or functional dyspepsia, was to assess the <jats:italic>H. pylori<\/jats:italic> cure rate after a 7\u2010day triple therapy with pantoprazole (40 mg bid) plus metronidazole (500 mg bid) and amoxicillin (1 g bid). The <jats:italic>H. pylori<\/jats:italic> status was assessed by rapid urease test, histological examination and culture at the initial examination and by histological examination and culture at the study end 4 weeks after ending all therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>At the end of the trial <jats:italic>H. pylori<\/jats:italic> was eradicated in 21 of 27 per protocol patients (78%; 95% CI 58\u201391%) and in 21 of 30 patients included in the trial (70%; 95% CI 51\u201385%). In 15 of 16 per protocol patients with metronidazole\u2010sensitive strain (94%; 95% CI 70\u2013100%) the infection was cured, but in contrast eradication was accomplished in only one of 3 patients with a metronidazole\u2010resistant <jats:italic>H. pylori<\/jats:italic> strain. Post\u2010treatment resistance to metronidazole was observed in 6 cases, although 4 of them had had <jats:italic>H. pylori<\/jats:italic> strains sensitive to metronidazole at the initial visit. The gastritis had clearly been improved, and the activity of gastritis had completely disappeared 4 weeks after treatment. Seven adverse events were observed in 7 patients, the intensity of which was moderate in 6 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>This short\u2010term triple therapy with pantoprazole, amoxicillin and metronidazole provides an effective regimen especially in patients with metronidazole\u2010sensitive strain.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1523-5378.1998.08044.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T23:20:56Z","timestamp":1047424856000},"page":"206-211","source":"Crossref","is-referenced-by-count":12,"title":["Cure of <i>H. pylori<\/i> Infection Using a 7\u2010Day Triple Therapy Combining Pantoprazole with Two Antibiotics"],"prefix":"10.1111","volume":"3","author":[{"given":"Romuald 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