{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T21:24:05Z","timestamp":1766697845414},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":663,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Recent studies have clarified a close association between <jats:italic>H. pylori<\/jats:italic> infection and gastritis, peptic ulcer disease, and gastric cancer, but there is little information concerning the relationship between <jats:italic>H. pylori<\/jats:italic> infection and reflux esophagitis (RE). We investigated the relationship between <jats:italic>H. pylori<\/jats:italic>, RE, and corpus gastritis.<\/jats:p><jats:p><jats:bold>Subjects and Methods.<\/jats:bold> Ninety\u2010five patients with RE and 190 sex\u2010 and age\u2010matched asymptomatic healthy controls demonstrating no localized lesions in the upper GI tract were studied and evaluated for <jats:italic>H. pylori<\/jats:italic> infection, histologic gastritis, serum gastrin, and pepsinogens (PGs).<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold>  <jats:italic>H. pylori<\/jats:italic> infection was significantly lower in RE patients than in asymptomatic controls (41% vs. 76%, <jats:italic>p<\/jats:italic> &lt; .01). Histologic gastritis of both the antrum and corpus was significantly less frequent (antrum; <jats:italic>p<\/jats:italic> &lt; .01, corpus; <jats:italic>p<\/jats:italic> &lt; .01), and serum levels of PGI and the PG I\/II ratio were significantly higher in RE patients than in controls (PGI; <jats:italic>p<\/jats:italic> &lt; .05, PG I\/II ratio; <jats:italic>p<\/jats:italic> &lt; .01). When the subjects were divided into two age groups (59 years of age and younger and 60 years of age and older), a significant difference was found only among patients over 60 years of age (29% vs. 85%, <jats:italic>p<\/jats:italic> &lt; .01). Among subjects in this age group, gastritis in both the antrum and corpus were significantly milder in RE patients than in controls. Although the prevalence of <jats:italic>H. pylori<\/jats:italic> infection was similar between the two groups of patients under 59 years of age, corpus gastritis was significantly milder in patients than in controls (<jats:italic>p<\/jats:italic> &lt; .05).<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> A significantly low prevalence of <jats:italic>H. pylori<\/jats:italic> infection was found in RE patients over 60 years of age but not in those under 59 in comparison with sex\u2010 and age\u2010matched controls. The relative lack of corpus gastritis might play a role in the pathogenesis of RE in our population through preservation of the acid secretion area.<\/jats:p>","DOI":"10.1046\/j.1523-5378.2000.00003.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T23:21:53Z","timestamp":1047424913000},"page":"24-29","source":"Crossref","is-referenced-by-count":69,"title":["Negative Association Between <i>Helicobacter pylori<\/i> Infection and Reflux Esophagitis in Older Patients: Case\u2010Control Study in Japan"],"prefix":"10.1111","volume":"5","author":[{"given":"Ken","family":"Haruma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshige","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoari","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Sumii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goro","family":"Kajiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kawanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.149.6.1373"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.72.846.221"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/10.1.38"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.1.9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70576-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70364-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199806000-00005"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018841222856"},{"key":"e_1_2_6_10_2","first-page":"235","article-title":"Gastric mucosal atrophy and prevalence of Helicobacter pylori in reflux esophagitis of the elderly.","volume":"93","author":"Ohara S","year":"1996","journal-title":"Jpn J Gastroenterology"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529509089783"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.6.648"},{"key":"e_1_2_6_13_2","first-page":"A1450","article-title":"Oesophagitis\u2014a five year review.","volume":"29","author":"Stoker DL","year":"1988","journal-title":"Gut"},{"key":"e_1_2_6_14_2","first-page":"668","article-title":"The incidence of reflux esophagitis among the Chinese.","volume":"92","author":"Chang CS","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90156-S"},{"key":"e_1_2_6_16_2","first-page":"959","article-title":"Helicobacter pylori infection is the major risk factor for atrophic gastritis.","volume":"91","author":"Kawaguchi H","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91084-0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528209181087"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0016-5085(82)90176-7","article-title":"Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology. 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