{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:10:59Z","timestamp":1767845459258,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":663,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> The best regimen for the treatment of <jats:italic>Helicobacter pylori<\/jats:italic> infection has yet to be defined. Four\u2010day quadruple therapy with tetracycline, metronidazole, bismuth, and a proton pump inhibitor has been shown to obtain a very high cure rate. However, the fact that it must be taken four times daily may interfere with compliance. The objective of the study was to test the efficacy and tolerability of a new 4\u2010day therapy with 4 drugs taken every 12 hours to cure <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><jats:p> <jats:bold>Patients and Methods.<\/jats:bold> Fifty\u2010six consecutive patients with peptic ulcer disease and <jats:italic>H. pylori<\/jats:italic> infection were treated with an oral 4\u2010day course with omeprazole (20 mg\/12 hours), clarithromycin (500 mg\/12 hours), amoxicillin (1 g\/12 hours) and tinidazole (500 mg\/12 hours). Efficacy of the treatment was determined at least 2 months after therapy either by biopsy (in the case of gastric ulcer) or by <jats:sup>13<\/jats:sup>C\u2010urea breath test. A second breath test was performed at least 6 months after therapy.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Two patients were lost to follow\u2010up. Forty\u2010nine of the remaining 54 patients were cured at the first control [intention\u2010to\u2010treat cure rate: 87.5% (CI 95% 75\u201394%); per protocol cure rate: 90.7% (CI 95% 81\u201398%)]. Forty\u2010three of these 49 cured patients returned for a second <jats:sup>13<\/jats:sup>C urea breath\u2010test at 6\u201312 months. Two of them were not cured, giving a long\u2010term cure rate of 85.5% per protocol and 73.2% by intention\u2010to\u2010treat. Compliance was good, although 25 patients had mild side effects.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold> This particular four\u2010day therapy is well tolerated, easy to follow, and achieves an acceptably high cure rate.<\/jats:p>","DOI":"10.1046\/j.1523-5378.2000.00007.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T23:21:53Z","timestamp":1047424913000},"page":"52-56","source":"Crossref","is-referenced-by-count":17,"title":["Four\u2010Day, Twice Daily, Quadruple Therapy with Amoxicillin, Clarithromycin, Tinidazole and Omeprazole to Cure <i>Helicobacter pylori<\/i> Infection: A Pilot Study"],"prefix":"10.1111","volume":"5","author":[{"given":"Xavier","family":"Calvet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ll\u00f9cia","family":"Tit\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricard","family":"Comet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neus","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralel","family":"Campo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enric","family":"Brullet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1072","article-title":"Choosing the best anti\u2010Helicobacter pylori therapy: effect of antimicrobial resistance.","volume":"91","author":"Graham DY","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1001\/jama.1996.03530320046033","article-title":"Consensus conference. 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