{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T19:25:39Z","timestamp":1746732339866},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":571,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> In developed countries, a 1\u2010week regimen of combined proton pump inhibitors and two antibiotics is considered adequate for <jats:italic>Helicobacter pylori<\/jats:italic> eradication. However, there is a paucity of reports from developing countries on treatment duration of less than 14 days. We compared efficacy of 7 and 14 days of lansoprazole (L), clarithromycin (C), and amoxicillin (A) combinations for eradication of <jats:italic>H. pylori.<\/jats:italic><\/jats:p><jats:p><jats:bold>Patients and Methods.<\/jats:bold> Forty\u2010six consecutive patients who presented with upper gastrointestinal symptoms and tested positive for <jats:italic>H. pylori<\/jats:italic> infection were included in the study. In every patient, after performance of upper gastrointestinal endoscopy, antral biopsies were obtained. <jats:italic>H. pylori<\/jats:italic> infection was diagnosed by positive rapid urease test and identification of organisms on antral histology. Patients were randomly selected to receive lansoprazole, 30 mg once daily, plus clarithromycin, 250 mg twice daily, plus amoxicillin, 500 mg three times daily for 2 weeks (\n\t\t\t\t\t<jats:roman>group<\/jats:roman> 1; \n\t\t\t\t\t<jats:roman>n<\/jats:roman> = 24; \n\t\t\t\t\t<jats:roman>age<\/jats:roman>, 36 \u00b1 12 \n\t\t\t\t\t<jats:roman>years<\/jats:roman>; 18 \n\t\t\t\t\t<jats:roman>men<\/jats:roman>) \n\t\t\t\t\t<jats:roman>or<\/jats:roman> 1 \n\t\t\t\t\t<jats:roman>week<\/jats:roman> (\n\t\t\t\t\t<jats:roman>group<\/jats:roman> 2; \n\t\t\t\t\t<jats:roman>n<\/jats:roman> = 22; \n\t\t\t\t\t<jats:roman>age<\/jats:roman>, 45 \u00b1 15 \n\t\t\t\t\t<jats:roman>years<\/jats:roman>; 12 \n\t\t\t\t\t<jats:roman>men<\/jats:roman>). One month after completion of treatment, repeat upper gastrointestinal endoscopy was performed. <jats:italic>H. pylori<\/jats:italic> eradication was defined as absence of organism on histopathological examination of both antrum and body of stomach and negative rapid urease test.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Eradication rate was higher in group 1 (23 of 24; 96%) as compared to group 2 (12 of 22; 54%; <jats:italic>p<\/jats:italic> &lt; .05). One patient in group 1 had diarrhea, and one patient in group two had skin rash and itching.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Fourteen\u2010day therapy with lansoprazole, clarithromycin, and amoxicillin is highly effective in eradication of <jats:italic>H. pylori.<\/jats:italic> Reducing duration of therapy to 7 days significantly lowers eradication rates.<\/jats:p>","DOI":"10.1046\/j.1523-5378.2000.00012.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T23:21:59Z","timestamp":1047424919000},"page":"84-87","source":"Crossref","is-referenced-by-count":22,"title":["Comparison of Seven and Fourteen Days of Lansoprazole, Clarithromycin, and Amoxicillin Therapy for Eradication of <i>Helicobacter pylori<\/i>: A Report from India"],"prefix":"10.1111","volume":"5","author":[{"given":"Deepak Kumar","family":"Bhasin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brijesh Chander","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pallab","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chander Mohan","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kartar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609094518"},{"key":"e_1_2_5_3_2","first-page":"156","article-title":"Pharmacological therapy of Helicobacter pylori infection.","volume":"8","author":"Hoffman JS","year":"1997","journal-title":"Semin Gastrointest Dis"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93181-8"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199906000-00013"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)80020-0"},{"key":"e_1_2_5_7_2","first-page":"S10","article-title":"Technical annex: tests used to assess Helicobacter pylori infection. Working Party of the European Helicobacter pylori Study Group.","volume":"41","author":"Anonymous","year":"1997","journal-title":"Gut"},{"key":"e_1_2_5_8_2","first-page":"97","article-title":"Efficacy of combination of omeprazole and erythromycin versus omeprazole and clarithromycin for eradication of Helicobacter pylori.","volume":"32","author":"Bhasin DK","year":"1998","journal-title":"Bull PGI"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91577-8"},{"issue":"1","key":"e_1_2_5_10_2","first-page":"689","article-title":"Relative merits of various rapid biopsy urease tests for diagnosis of Helicobacter pylori.","volume":"38","author":"Bhasin DK","year":"1990","journal-title":"J Assoc Phys India"},{"key":"e_1_2_5_11_2","first-page":"45","article-title":"Diagnosis of Helicobacter pylori infection.","volume":"32","author":"Sharma BC","year":"1998","journal-title":"Bull PGI"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00280.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.15.1651"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.1996.tb00045.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.169_b.x"},{"key":"e_1_2_5_16_2","first-page":"A94","article-title":"Treatment of Helicobacter pylori infection with different doses of clarithromycin combined with amoxicillin and lansoprazole [abstract].","volume":"112","author":"Costa F","year":"1998","journal-title":"Gastroenterology"},{"key":"e_1_2_5_17_2","first-page":"651","article-title":"Duodenal ulcer healing after 7 days treatment: A pilot study with lansoprazole, amoxicillin and clarithromycin.","volume":"33","author":"Schutze K","year":"1995","journal-title":"Z Gastroenterol"},{"key":"e_1_2_5_18_2","first-page":"1668","article-title":"Short term low dose triple therapy with lansoprazole plus amoxicillin and clarithromycin for Helicobacter pylori eradication.","volume":"8","author":"Tursi A","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1996.d01-533.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00184.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00319.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.6.735"},{"key":"e_1_2_5_23_2","first-page":"A168","article-title":"Randomised comparison of 7, 10 and 14 days of omeprazole, amoxicillin and clarithromycin for treatment of H. pylori[abstract].","volume":"110","author":"Laine L","year":"1996","journal-title":"Gastroenterology"},{"issue":"1","key":"e_1_2_5_24_2","first-page":"A100","article-title":"Eradication of H. pylori infection with two triple therapy regimens of 7 and 14 days duration [abstract].","volume":"41","author":"Katicic M","year":"1997","journal-title":"Gut"},{"issue":"1","key":"e_1_2_5_25_2","first-page":"A94","article-title":"Triple therapy omeprazole (O) amoxicillin (A) and clarithromycin (C) for Helicobacter pylori (HP) infection. 6 vs 12 days. Results and cost analysis [abstract].","volume":"41","author":"Hermida C","year":"1997","journal-title":"Gut"},{"issue":"1","key":"e_1_2_5_26_2","first-page":"A99","article-title":"A multicenter study of lansoprazole combined with antibiotics to eradicate Helicobacter pylori infection in the patients with duodenal ulcer [abstract].","volume":"41","author":"Yang JC","year":"1997","journal-title":"Gut"},{"issue":"1","key":"e_1_2_5_27_2","first-page":"A96","article-title":"A new dual 7 day therapy is effective in eradicating Helicobacter pylori in duodenal ulcer patients [abstract].","volume":"41","author":"Cardelli A","year":"1997","journal-title":"Gut"},{"key":"e_1_2_5_28_2","first-page":"A101","article-title":"10 vs 14 days triple therapy with lansoprazole (Prevacid), amoxicillin and clarithromycin in the eradication of Helicobacter pylori (Hp) [abstract].","volume":"41","author":"Krause R","year":"1997","journal-title":"Gut"},{"issue":"1","key":"e_1_2_5_29_2","first-page":"A95","article-title":"7 vs 14 days treatment with pantoprazole, clarithromycin and metronidazole for cure of H. pylori infection in duodenal ulcer patients [abstract].","volume":"41","author":"Damman HG","year":"1997","journal-title":"Gut"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.6.781"},{"key":"e_1_2_5_31_2","doi-asserted-by":"crossref","unstructured":"Peura DA. The report of Digestive Health Initiative International Update Conference onHelicobacter pylori. 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