{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:20:53Z","timestamp":1759990853928},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,8,5]],"date-time":"2002-08-05T00:00:00Z","timestamp":1028505600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background.<\/jats:bold> Phospholipids concentration in the gastric mucosa decreased in patients with <jats:italic>Helicobacter pylori<\/jats:italic> infection. The aim of this study is to examine the effects of eradication of <jats:italic>H. pylori<\/jats:italic> on decreasing the phospholipids concentration in the gastric mucosa in patients with gastric or duodenal ulcer.<\/jats:p><jats:p><jats:bold>Materials and Methods.<\/jats:bold> Phospholipids (phosphatidylcholine, phosphatidylethanolamine, and sphingonomyeline) were measured in biopsy specimens from the antrum and corpus using thin\u2010layer chromatography. In <jats:italic>H. pylori<\/jats:italic> positive patients with gastric ulcer (n\u00a0=\u00a026) and duodenal ulcer (n\u00a0=\u00a013), and <jats:italic>H. pylori<\/jats:italic> negative controls (n\u00a0=\u00a020), the biopsy specimens were obtained before and 3\u00a0months after eradication. Eradication was performed using lansoprazole, amoxycillin, and clarithromycin.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Compared with the <jats:italic>H. pylori<\/jats:italic> negative control group, the concentrations of phosphatidylcholine and phosphatidylethanolamine decreased significantly in the gastric ulcer group in both antrum and corpus mucosa, and in the duodenal ulcer group in antrum mucosa. This decrease returned to the control level after eradication.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> This study demonstrates that the eradication of <jats:italic>H. pylori<\/jats:italic> in patients with peptic ulcer normalized the decrease of phosphatidylcholine and phosphatidylethanolamine in the gastric mucosa.<\/jats:p>","DOI":"10.1046\/j.1523-5378.2002.00086.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T23:23:25Z","timestamp":1047425005000},"page":"245-249","source":"Crossref","is-referenced-by-count":8,"title":["Normalization of Phospholipids Concentration of the Gastric Mucosa was Observed in Patients with Peptic Ulcer after Eradication of <i>Helicobacter 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