{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:46:32Z","timestamp":1792277192451,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":542,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract:<\/jats:bold>\n                    The natural history of atopic dermatitis (AD) is variable. Generally the dermatitis disappears during the first years of life, but it is often followed by the appearance of allergic respiratory diseases (ARDs). Our aim was to establish the risk factors for developing an ARD in children with AD. We followed up for 4 years 78 children (51 boys, 27 girls) with mild (26%), moderate (48%), and severe (26%) AD (clinical score proposed by Rajka and Langeland). In all the patients IgE serum levels were checked and skin prick tests (SPTs) were performed at the first examination. The SPTs were repeated in 68 children at the end of the study. The children with severe AD had significantly higher IgE serum levels than those with mild or moderate AD. SPTs at the first observation were positive in 47% of cases, mostly in patients with severe AD, with a prevalence of food allergens, particularly in younger patients. At the second observation, SPTs were positive in 65% of cases, including 100% of children with severe AD. Inhalants were the most common allergens. An ARD appeared in 38% of all patients: in 75% of those with severe AD and in 54% of those with a positive first SPT. Allergic screening should be carried out at an early age, especially in severe AD, since SPT positivity to food allergens, associated with severe clinical AD symptoms and a high IgE serum level, identifies those children ages 0\u20133 years at high risk of development of ARD.\n                  <\/jats:p>","DOI":"10.1046\/j.1525-1470.2000.01771.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T11:40:48Z","timestamp":1047469248000},"page":"261-265","source":"Crossref","is-referenced-by-count":25,"title":["The Natural History of Sensitizations to Food and Aeroallergens in Atopic Dermatitis: A 4\u2010Year\u2003Follow\u2010Up"],"prefix":"10.1111","volume":"17","author":[{"given":"Annalisa","family":"Patrizi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Guerrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaolo","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iria","family":"Neri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Specchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Masi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000250188"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1976.tb00837.x"},{"key":"e_1_2_7_4_2","first-page":"87","article-title":"A prospective computerized study of 500 cases of atopic dermatitis in childhood.","volume":"114","author":"Queille\u2010Roussel C","year":"1985","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90295-3"},{"key":"e_1_2_7_6_2","first-page":"205","article-title":"Implicazioni cliniche della sensibilizzazione ad inalanti nella dermatite atopica.","volume":"44","author":"Monafo V","year":"1992","journal-title":"Minerva Pediatr"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1991.tb02641.x"},{"key":"e_1_2_7_8_2","first-page":"117","article-title":"Long term follow\u2010up in atopic dermatitis.","volume":"114","author":"Rysted I","year":"1985","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1992.tb12165.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic features of atopic dermatitis.","volume":"92","author":"Hanjfin JM","year":"1980","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_7_11_2","first-page":"13","article-title":"Grading of the severity of atopic dermatitis.","volume":"144","author":"Rajka G","year":"1989","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_7_12_2","first-page":"4","article-title":"La dermatite atopica nell'infanzia: approccio diagnostico e terapeutico.","volume":"1","author":"Vierucci A","year":"1991","journal-title":"Riv Immunol Allergol Ped"},{"key":"e_1_2_7_13_2","first-page":"337","article-title":"Taux d'IgE seriques dans l'eczema atopique de l'enfant.","volume":"4","author":"Desmons F","year":"1976","journal-title":"Pediatrie"},{"key":"e_1_2_7_14_2","first-page":"469","article-title":"Atopic dermatitis.","volume":"69","author":"Sampson HA","year":"1992","journal-title":"Ann Allergy"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000248388"},{"key":"e_1_2_7_16_2","first-page":"177","article-title":"Predictivity of prick test and RAST\u2010positive reactions for inhaled allergens in children with atopic dermatitis for the appearance of respiratory allergic disease.","volume":"4","author":"Ricci G","year":"1991","journal-title":"Pharmacol Skin"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1001\/archderm.1992.01680120059004","article-title":"Natural history of sensitizations in atopic dermatitis. A 3\u2010year follow\u2010up in 250 children: food allergy and high risk of respiratory symptoms.","volume":"128","author":"Guillet G","year":"1992","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70074-9"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(74)90037-2"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.112.9.1254"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90486-7"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90184-8"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70021-6"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90086-7"},{"key":"e_1_2_7_26_2","first-page":"20","article-title":"Adverse reactions to foods: epidemiology and risk factors.","volume":"6","author":"Host A","year":"1995","journal-title":"Pediatr Allergy Immunol"},{"key":"e_1_2_7_27_2","volume-title":"Epidemiology and natural history of atopic dermatitis","author":"Wuthrich B","year":"1996"},{"key":"e_1_2_7_28_2","first-page":"203","volume-title":"Intestinal immunology and food allergy","author":"Zeiger RS","year":"1995"},{"key":"e_1_2_7_29_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1542\/peds.91.1.8","article-title":"Prevalence of respiratory symptoms in children with atopic dermatitis attending pediatric dermatology clinics.","volume":"91","author":"Salob ST","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_7_30_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1542\/peds.91.1.13","article-title":"Bronchial hyperresponsiveness in children with atopic dermatitis.","volume":"91","author":"Salob ST","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_7_31_2","first-page":"145","article-title":"Storia naturale della dermatite atopica nel bambino.","volume":"8","author":"Novembre E","year":"1998","journal-title":"Eur J Pediatr Dermatol"},{"key":"e_1_2_7_32_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2340\/0001555572261263","article-title":"Objective prick test evaluation: non\u2010invasive techniques.","volume":"72","author":"Berardesca E","year":"1992","journal-title":"Acta Derm Venereol (Stockh)"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1525-1470.2000.01771.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1525-1470.2000.01771.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1046\/j.1525-1470.2000.01771.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1525-1470.2000.01771.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:48:20Z","timestamp":1772977700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1525-1470.2000.01771.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1046\/j.1525-1470.2000.01771.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1525-1470.2000.01771.x","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}