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We used immunohistochemistry to analyze the distribution of TNF, TNF\u2010releasing MMPs, including gelatinases (MMP\u20102 and MMP\u20109), and TNF\u2010\u03b1 converting enzyme (TACE) in painful neuropathy caused by chronic constriction injury of rat sciatic nerve. Tissue was analyzed at the injury site and in the corresponding L4 and L5 dorsal root ganglia (DRG) throughout the time\u2010course of the neuropathy. Using confocal laser scanning microscopy, we co\u2010localized TNF with each MMP, and observed spatial and temporal distinction in their distribution. TNF co\u2010localized in vessel endothelium with MMP\u20102 and in macrophages with MMP\u20109 and TACE at the period of active immune cell migration. TNF co\u2010localized with myelin degrading MMP\u20109 within Schwann cells during demyelination, and intraaxonally during remyelination. These studies were performed to explore the role of basal\u2010lamina degrading gelatinases and other TNF\u2010releasing MMPs in TNF\u2010mediated Wallerian degeneration. The data provided in this study may be useful in designing selective therapy for painful neuropathy using synthetic hydroxamate MMP inhibitors.<\/jats:p>","DOI":"10.1046\/j.1529-8027.2002.02003.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T07:18:21Z","timestamp":1047453501000},"page":"28-36","source":"Crossref","is-referenced-by-count":60,"title":["Endoneurial remodeling by TNF\u03b1 and TNF\u03b1\u2010releasing proteases. 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