{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:11:29Z","timestamp":1775077889155,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,4,21]],"date-time":"2002-04-21T00:00:00Z","timestamp":1019347200000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold>A laboratory measure that predicted the timing of platelet recovery after chemotherapy could guide prophylactic platelet transfusion. Reticulated platelets (RPs) are the youngest circulating platelets; an increased percentage of RPs is diagnostic of increased marrow platelet production, such as seen with idiopathic thrombocytopenic purpura, whereas a low percentage of RPs with thrombocytopenia indicates marrow suppression. This study examined whether the percentage of RPs, in combination with a newly devised measurement of \"stress thrombopoiesis,\" the RP maturation index (RP\u2010MI), could predict platelet count recovery following chemotherapy\u2010induced thrombocytopenia.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold>Platelet count nadirs were retrospectively determined in 35 chemotherapy\u2010induced thrombocytopenia patients; percentage of RPs and RP\u2010MI values were assayed at the early nadir (no imminent platelet recovery) and the late nadir (imminent platelet recovery). The latter was defined by a platelet count increase of 20 \u00d7 10<jats:sup>9<\/jats:sup>per L or more in the subsequent 48 hours without platelet transfusion.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold>Early in the nadir (when platelet recovery did not occur in the subsequent 48 h after sampling), a low RP\u2010MI and a low percentage of RPs were found in 29 of 35 patients. Late in the nadir, when recovery was imminent, 27 of 30 evaluable patients had elevated percentages of RPs or RP\u2010MI values; the mean time from sampling to an increase of 20 \u00d7 10<jats:sup>9<\/jats:sup>per L or more was 42 hours. The positive and negative predictive values of this assay were 82 and 91 percent, respectively. Furthermore, when thrombocytopenia was severe (platelet count \u226420 \u00d7 10<jats:sup>9<\/jats:sup>\/L), an elevated RP\u2010MI and\/or percentage of RPs correctly predicted imminent platelet count recovery in five of five patients.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold>This noninvasive, rapid, whole\u2010blood assay of stress thrombopoiesis provides reproducible indices for timing platelet recovery following chemotherapy and the potential to optimize the use of prophylactic platelet transfusions in chemotherapy patients.<\/jats:p>","DOI":"10.1046\/j.1537-2995.2002.00040.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T22:49:42Z","timestamp":1047509382000},"page":"368-374","source":"Crossref","is-referenced-by-count":45,"title":["Reticulated platelets predict platelet count recovery following chemotherapy"],"prefix":"10.1111","volume":"42","author":[{"given":"Chao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian\u2003R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth\u2003A.","family":"Ault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry\u2003M.","family":"Rinder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1182\/blood.V85.7.1822.bloodjournal8571822","article-title":"Demonstration that thiazole orange\u2010positive platelets in the dog are less than 24 hours old.","volume":"85","author":"Dale GL","year":"1995","journal-title":"Blood"},{"key":"e_1_2_5_3_2","first-page":"996","article-title":"In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in the circulation.","volume":"23","author":"Ault KA","year":"1995","journal-title":"Exp Hematol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1182\/blood.V75.1.116.116","article-title":"Flow cytometric analysis of thiazole orange uptake by platelets: a diagnostic aid in the evaluation of thrombocytopenic patients.","volume":"75","author":"Kienast J","year":"1990","journal-title":"Blood"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/98.6.637"},{"key":"e_1_2_5_6_2","first-page":"606","article-title":"Reticulated platelets in the evaluation of thrombopoietic disorders.","volume":"117","author":"Rinder HM","year":"1993","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70253-6"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70395-7"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830460411"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1182\/blood.V91.4.1288","article-title":"Correlation of thrombosis with increased platelet turnover in thrombocytosis.","volume":"91","author":"Rinder HM","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1182\/blood.V66.5.1105.1105","article-title":"Platelet kinetics in patients with bone marrow hypoplasia: evidence for a fixed platelet requirement.","volume":"66","author":"Hanson SR","year":"1985","journal-title":"Blood"},{"key":"e_1_2_5_12_2","first-page":"295","article-title":"Stress platelets in normal individuals and patients with idiopathic thrombocytopenic purpura.","volume":"18","author":"Hattori A","year":"1992","journal-title":"Blood Cells"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6661(199901\/02)8:1<1::AID-MFM1>3.0.CO;2-O"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005990050011"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/108.1.69"},{"key":"e_1_2_5_16_2","first-page":"1029","article-title":"Measurement of reticulated platelets following peripheral blood progenitor cell and bone marrow transplantation: implications for marrow reconstitution and the use of thrombopoietin.","volume":"17","author":"Richards EM","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1998.00348.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050513"},{"key":"e_1_2_5_19_2","unstructured":"Jandl JH. 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