{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:52:39Z","timestamp":1790419959496,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,4,21]],"date-time":"2002-04-21T00:00:00Z","timestamp":1019347200000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p> <jats:bold>BACKGROUND:<\/jats:bold> Hemolytic transfusion reactions have been observed in recipients of ABO\u2010 and\/or D\u2010mismatched marrow, peripheral blood, and solid organs. Passenger lymphocyte syndrome occurs when immunocompetent donor lymphocytes transferred during transplantation produce alloantibodies against host antigens.<\/jats:p><jats:p> <jats:bold>CASE REPORT:<\/jats:bold> The first case of a delayed, anti\u2010Jk<jats:sup>a<\/jats:sup>\u2010mediated hemolytic reaction in a liver transplant recipient, caused by passenger donor lymphocytes, is reported here. A 43\u2010year\u2010old man underwent liver transplantation. Six weeks later, the patient underwent a second liver transplant. On Day 10 of the second transplant, clinical hemolysis ensued; anti\u2010Jk<jats:sup>a<\/jats:sup> was detected. The patient's DAT became positive, and anti\u2010Jk<jats:sup>a<\/jats:sup> was eluted from his RBCs. On Day 35 of the patient's second transplant, 3 weeks after the last blood transfusion, the patients' DAT was still weakly positive with anti\u2010Jk<jats:sup>a<\/jats:sup> in the eluate. Six months later, serum antibody screening was negative, but the DAT was still weakly positive. The patient's RBCs tested Jk(a+), whereas the second donor's RBCs were Jk(a\u2212).<\/jats:p><jats:p> <jats:bold>CONCLUSION:<\/jats:bold> This is the first documentation of clinically significant hemolysis caused by anti\u2010Jk<jats:sup>a<\/jats:sup>, produced by passenger lymphocytes transferred from the donor's liver to the transplant recipient.<\/jats:p>","DOI":"10.1046\/j.1537-2995.2002.00075.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T22:49:42Z","timestamp":1047509382000},"page":"363-367","source":"Crossref","is-referenced-by-count":31,"title":["Donor anti\u2010Jk<sup>a<\/sup> causing hemolysis in a liver transplant recipient"],"prefix":"10.1111","volume":"42","author":[{"given":"Mara","family":"Hareuveni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadar","family":"Merchav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neomi","family":"Austerlitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neomi","family":"Rahimi\u2010Leveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofira","family":"Ben\u2010Tal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38398222864.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700641"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1182\/blood.V67.1.177.177","article-title":"Donor\u2010derived 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