{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:07:27Z","timestamp":1794002847572,"version":"4.8.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T00:00:00Z","timestamp":1034035200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p> <jats:bold>BACKGROUND<\/jats:bold> : Hemolysis as a result of donor\u2010recipient minor ABO mismatching is a complication of allogeneic peripheral blood progenitor cell (PBPC) transplantation (PBPCT). The increased B\u2010lymphocyte content of PBPC grafts and immunosuppressive regimens without methotrexate (MTX) may increase incidence and severity of this event.<\/jats:p><jats:p> <jats:bold>STUDY DESIGN AND METHODS<\/jats:bold> : A total of 93 patients were analyzed after allogeneic PBPCT. In 25 (27%) cases, minor (n = 21) or bidirectional (n = 4) ABO mismatching was present. Of these, 15 patients received myeloablative and 10 received nonmyeloablative conditioning regimens. For GVHD, prophylaxis cyclosporin A (CsA) alone (n = 2) or CsA with MTX (n = 13) was given after myeloablative conditioning and CsA with mycophenolate mofetil (MMF) after nonmyeloablative conditioning (n = 10).<\/jats:p><jats:p> <jats:bold>RESULTS<\/jats:bold> : Hemolysis occurred in 4 out of 25 (16%) patients with minor or bidirectional ABO mismatching only. Three patients underwent nonmyeloablative conditioning and were given CsA with MMF, and one patient underwent myeloablative conditioning and was given CsA alone for GVHD prophylaxis. Hemolysis began 7 to 10 days after transplantation, and donor type alloantibodies were detectable concomitantly with recipients type RBCs.<\/jats:p><jats:p> <jats:bold>CONCLUSION<\/jats:bold> : Patients receiving minor or bidirectional ABO\u2010mismatched PBPC grafts and GVHD prophylaxis without MTX are at risk of hemolysis. Prophylactic interventions in patients before minor ABO\u2010mismatched PBPCT not receiving MTX should be taken into con\u2010 sideration. Careful monitoring of hemolysis parameters during the first 15 days after PBPCT transplantation is mandatory.<\/jats:p>","DOI":"10.1046\/j.1537-2995.2002.00209.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T22:48:45Z","timestamp":1047509325000},"page":"1293-1301","source":"Crossref","is-referenced-by-count":77,"title":["Severe immune hemolysis after minor ABO\u2010mismatched allogeneic peripheral blood progenitor cell transplantation occurs more frequently after nonmyeloablative than myeloablative conditioning"],"prefix":"10.1111","volume":"42","author":[{"given":"Nina","family":"Worel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildegard T.","family":"Greinix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Keil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Mitterbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Lechner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"H\u00f6cker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kalhs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198803000-00005"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38398222864.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198204000-00017"},{"key":"e_1_2_5_5_2","first-page":"159","article-title":"Immunohematologic complications of bone marrow transplantation.","volume":"8","author":"Klumpp TR","year":"1991","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40050543.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1182\/blood.V67.1.177.177","article-title":"Donor\u2010derived red blood cell antibodies and immune hemolysis after allogeneic bone marrow transplantation.","volume":"67","author":"Hows J","year":"1986","journal-title":"Blood"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1182\/blood.V79.11.3076.bloodjournal79113076","article-title":"Hemolysis of transfused group O red blood cells in minor ABO\u2010incompatible unrelated\u2010donor bone marrow transplants in patients receiving cyclosporine without posttransplant methotrexate.","volume":"79","author":"Gajewski JL","year":"1992","journal-title":"Blood"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101183440303"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701234"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701505"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2817"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood.V91.3.756","article-title":"Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases.","volume":"91","author":"Slavin S","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.7.2044"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3390"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700794"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39080824.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02587.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1182\/blood.V87.2.843.bloodjournal872843","article-title":"Passenger B\u2010lymphocyte\u2010induced severe hemolytic disease after allogeneic peripheral blood stem cell transplantation (letter).","volume":"87","author":"Toren A","year":"1996","journal-title":"Blood"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2001.00334.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700641"},{"key":"e_1_2_5_22_2","unstructured":"Hansen JA Mickelson EM et al. 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