{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:27:18Z","timestamp":1761560838570},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,8,13]],"date-time":"2003-08-13T00:00:00Z","timestamp":1060732800000},"content-version":"vor","delay-in-days":742,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p> <jats:bold>Atrial Defibrillation Thresholds.<\/jats:bold>\n          <jats:italic>Introduction:<\/jats:italic> Little investigation has been conducted to assess the atrial defibrillation thresholds of electrode configurations using electrodes designed for internal ventricular defibrillation (right ventricle [RV], superior vena cava [SVC], and pulse generator housing [Can]) combined with coronary sinus (CS) electrodes. We hypothesized that a CS \u2192 SVC+Can electrode configuration would have a lower atrial defibrillation threshold than a standard configuration for defibrillation, RV \u2192 SVC+Can. We also tested the atrial defibrillation thresholds of five other configurations.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> In 12 closed chest sheep, we situated a two\u2010coil (RV, SVC) defibrillation catheter, a left\u2010pectoral subcutaneous Can, and a CS lead. Atrial fibrillation was burst induced and maintained with continuous infusion of intrapericardial acetyl\u2010\u03b2\u2010methylcholine chloride. Using fixed\u2010tilt biphasic shocks, we determined the atrial defibrillation thresholds of seven test configurations in random order according to a multiple\u2010reversal protocol. The peak voltage and delivered energy atrial defibrillation thresholds of CS \u2192 SVC+Can (<jats:styled-content>168 \u00b1 67 V, 2.68 \u00b1 2.40 J<\/jats:styled-content>) were significantly lower than those of RV \u2192 SVC+Can (<jats:styled-content>215 \u00b1 88 V, 4.46 \u00b1 3.40 J<\/jats:styled-content>). The atrial defibrillation thresholds of the other test configurations were <jats:styled-content>RV+CS \u2192 SVC+Can 146 \u00b1 59V, 1.92 \u00b1 1.45 J; RV \n\u2028\u2192 CS+SVC+Can:191 \u00b1 89V, 3.53 \u00b1 3.19 J; CS \u2192\u2028SVC: 188 \u00b1 98V, 3.77 \u00b1 4.14 J; SVC \u2192 CS+Can: 265 \u00b1\u2028145 V, 7.37 \u00b1 9.12 J; and SVC \u2192 Can: 516 \u00b1 209 V, \n\u202824.5 \u00b1 15.0 J.<\/jats:styled-content><\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> The atrial defibrillation threshold of CS \u2192 RV SVC+Can. In addition, the low atrial defibrillation threshold of RV+CS \u2192 SVC+Can merits further investigation. Based on corroboration of low atrial defibrillation thresholds of CS\u2010based configurations in humans, physicians might consider using CS leads with atrioventricular defibrillators.<\/jats:p>","DOI":"10.1046\/j.1540-8167.2001.00957.x","type":"journal-article","created":{"date-parts":[[2003,8,13]],"date-time":"2003-08-13T14:03:30Z","timestamp":1060783410000},"page":"957-964","source":"Crossref","is-referenced-by-count":13,"title":["Atrial Defibrillation Thresholds of Electrode Configurations Available to an Atrioventricular Defibrillator"],"prefix":"10.1111","volume":"12","author":[{"given":"MICHAEL E.","family":"BENSER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GREGORY P.","family":"WALCOTT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHERYL R.","family":"KILLINGSWORTH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEVEN D.","family":"GIROUARD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MILTON M.","family":"MORRIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAYMOND E.","family":"IDEKER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8,13]]},"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1540-8167.2001.00957.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1540-8167.2001.00957.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T14:35:40Z","timestamp":1700404540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1540-8167.2001.00957.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1046\/j.1540-8167.2001.00957.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1540-8167.2001.00957.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}