{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:41:02Z","timestamp":1762504862549},"reference-count":0,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2003,8,13]],"date-time":"2003-08-13T00:00:00Z","timestamp":1060732800000},"content-version":"vor","delay-in-days":650,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:p> <jats:bold>Dual\u2010Chamber ICD and Atrial Tachyarrhythmia. <\/jats:bold>\n          <jats:italic>Introduction:<\/jats:italic> This study evaluated the safety and efficacy of a new dual\u2010chamber implantable cardioverter defibrillator (ICD) to detect and treat atrial tachyarrhythmias in patients with drug\u2010refractory atrial fibrillation (AF) and no indication for a ventricular ICD.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> A dual\u2010chamber ICD (Medtronic 7250 Jewel AF) was implanted in 144 of 146 patients. The device discriminates atrial tachycardia from AF based on cycle length and regularity, and uses atrial overdrive pacing as well as shocks to terminate tachyarrhythmia episodes. Patients were followed for an average of <jats:styled-content>12.6 \u00b1 6.2 months<\/jats:styled-content>. Use of antiarrhythmic drugs was 63% at baseline and did not change over time. Kaplan\u2010Meier estimates of 12\u2010month complication\u2010free survival, device therapy survival, and patient survival were 85%, 91%, and 98%, respectively. Positive predictive accuracy of spontaneous atrial tachyarrhythmia detection was 99%, while atrial overdrive pacing and shocks terminated 40% and 87% of treated episodes, respectively. Median duration of successfully treated episodes was 8.9 minutes versus 144 minutes for the therapy failures. There was no reduction in the use of patient\u2010activated shock therapy over time; at the 12\u2010month follow\u2010up evaluation, 94% of patients were in sinus rhythm. Ventricular tachyarrhythmias (67 episodes) were detected and appropriately treated in 7.6% of patients.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> This dual\u2010chamber ICD appears to be safe and well tolerated in patients with drug\u2010refractory symptomatic atrial tachyarrhythmias. The device, used in combination with drugs, effectively treats atrial tachyarrhythmias with pacing and\/or shock therapies and decreases the median episode duration. In addition, the device protects from ventricular tachyarrhythmias in patients with AF and structural heart disease.<\/jats:p>","DOI":"10.1046\/j.1540-8167.2001.01247.x","type":"journal-article","created":{"date-parts":[[2003,8,13]],"date-time":"2003-08-13T11:22:11Z","timestamp":1060773731000},"page":"1247-1253","source":"Crossref","is-referenced-by-count":78,"title":["Clinical Experience with a Dual\u2010Chamber Implantable Cardioverter Defibrillator to Treat Atrial Tachyarrhythmias"],"prefix":"10.1111","volume":"12","author":[{"given":"MICHAEL R.","family":"GOLD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NEIL","family":"SULKE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID S.","family":"SCHWARTZMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAHUL","family":"MEHRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID E.","family":"EULER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8,13]]},"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1540-8167.2001.01247.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1540-8167.2001.01247.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T14:05:36Z","timestamp":1700402736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1540-8167.2001.01247.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["10.1046\/j.1540-8167.2001.01247.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1540-8167.2001.01247.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}