{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T05:46:40Z","timestamp":1713505600877},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T00:00:00Z","timestamp":1060646400000},"content-version":"vor","delay-in-days":407,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p> <jats:bold>Nonexcitatory Stimulation.<\/jats:bold>\n          <jats:italic>Introduction:<\/jats:italic> Preliminary data in a heart failure animal model and isolated muscle preparation have suggested that nonexcitatory stimulation (NES) improves left ventricular (LV) function.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> We compared biventricular (BV) pacing with NES in an animal model with left bundle branch block (LBBB). The left bundle branch (LBB) was ablated in eight normal heart pigs and led to &gt; 50% increase in QRS duration (mean <jats:styled-content>100 \u00b1 15<\/jats:styled-content> msec). End\u2010diastolic LV pressure, end\u2010systolic LV pressure, LV pressure (LV dP\/dt<jats:sub>max<\/jats:sub>), aortic pulse pressure, and LV ejection fraction were measured before pre\u2010LBB ablation and compared with post\u2010LBB ablation (AAI pacing), BV pacing, NES delivery, and BV + NES. Moreover, to evaluate LV diastolic function, we measured the early (E wave) and late flows (A wave) through the mitral valve using spectral Doppler. Compared with post\u2010LBB ablation, NES led to a significant increase in LV dP\/dt<jats:sub>max<\/jats:sub> (<jats:styled-content>1,047 \u00b1 224 mmHg\/sec vs 897 \u00b1 116 mmHg\/sec; P &lt; 0.05<\/jats:styled-content>), LV ejection fraction (<jats:styled-content>64% \u00b1 18% vs 49% \u00b1 17%; P &lt; 0.05<\/jats:styled-content>), and aortic pulse pressure (<jats:styled-content>18 \u00b1 3.6 mmHg vs 16 \u00b1 2.8 mmHg; P &lt; 0.05<\/jats:styled-content>). Moreover, improvement in LV hemodynamic parameters was significantly higher during NES delivery when compared with BV pacing. No significant changes in E wave, A wave, and E\/A were recorded during NES, NES + BV, and BV pacing.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> Our preliminary data demonstrate that NES is superior to BV pacing in improving LV function in an animal model with LBBB. Moreover, we demonstrated that NES does not affect transmitral valve flow and subsequently LV diastolic function.<\/jats:p>","DOI":"10.1046\/j.1540-8167.2002.00691.x","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T15:22:51Z","timestamp":1060701771000},"page":"691-695","source":"Crossref","is-referenced-by-count":9,"title":["Nonexcitatory Stimulus Delivery Improves Left Ventricular Function in Hearts with Left Bundle Branch Block"],"prefix":"10.1111","volume":"13","author":[{"given":"NASSIR F.","family":"MARROUCHE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN V.","family":"PAVIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHAOWEI","family":"ZHUANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUNG\u2010JIN","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOMOTSUGU","family":"TABATA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DON","family":"WALLICK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EDUARDO","family":"SAAD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AHMAD","family":"ABDUL\u2010KARIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT","family":"SCHWEIKERT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WALID","family":"SALIBA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRICK","family":"TCHOU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREA","family":"NATALE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8,12]]},"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1540-8167.2002.00691.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1540-8167.2002.00691.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T08:18:17Z","timestamp":1700295497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1540-8167.2002.00691.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["10.1046\/j.1540-8167.2002.00691.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1540-8167.2002.00691.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}