{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T03:46:45Z","timestamp":1766807205902},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,4,11]],"date-time":"2003-04-11T00:00:00Z","timestamp":1050019200000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p> <jats:bold>\n            <jats:italic>Introduction:<\/jats:italic> ST segment elevation in patients with Brugada syndrome is known to fluctuate occasionally, influenced by multiple factors. Insulin has been shown to affect QT dispersion in healthy volunteers, as well as result in abnormality of ventricular repolarization in patients with congenital long QT syndrome.<\/jats:bold> <\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods and Results:<\/jats:italic> To assess a possible role of insulin in ST segment elevation in patients with Brugada syndrome, an oral glucose tolerance test (OGTT) was administered to 20 patients with Brugada syndrome and 20 normal patients without ST\u2010T changes as a control group. Plasma glucose and potassium levels, immunoreactive insulin concentration (IRI), and ST segment elevation and ST\u2010T wave changes on 12\u2010lead ECG during OGTT were analyzed. Augmentation (&gt;1 mm) of ST elevation or morphologic changes in ST\u2010T waves were observed frequently in response to increased IRI during OGTT [15\/20 cases (75%)] in patients with Brugada syndrome but in none of the patients in the control group [0\/20 cases (0%),<\/jats:bold>\n          <jats:styled-content>\n              <jats:bold>P &lt; 0.01<\/jats:bold>\n            <\/jats:styled-content>\n          <jats:bold>]. The changes returned to baseline 180 minutes after the glucose load in 9 of 15 patients. Patients who showed coved\u2010type ST elevation before the glucose load exhibited positive ECG changes more frequently than patients with saddleback\u2010type elevation or transiently normalized ST segment [8\/8 cases (100%) vs 7\/12 (58%),<\/jats:bold>\n          <jats:styled-content>\n              <jats:bold>P &lt; 0.05<\/jats:bold>\n            <\/jats:styled-content>\n          <jats:bold>]. There was no significant difference between the two groups in terms of glucose, IRI, and potassium levels during OGTT.<\/jats:bold> <\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic> The findings suggest that glucose\u2010induced insulin secretion is one of the contributing factors to fluctuation of ST segment elevation in patients with Brugada syndrome.<\/jats:bold>\n          <jats:italic>(J Cardiovasc Electrophysiol, Vol. 14, pp. 243\u2010249, March 2003)<\/jats:italic> <\/jats:p>","DOI":"10.1046\/j.1540-8167.2003.02389.x","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T09:42:39Z","timestamp":1281951759000},"page":"243-249","source":"Crossref","is-referenced-by-count":53,"title":["Effects of Glucose\u2010Induced Insulin Secretion on ST Segment Elevation in the Brugada 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