{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:42:33Z","timestamp":1790419353826,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,3,28]],"date-time":"2003-03-28T00:00:00Z","timestamp":1048809600000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p> <jats:bold>Septal Activation in Patients with LBBB and Heart Failure.<\/jats:bold>\n          <jats:italic>Introduction:<\/jats:italic> Little is known about the septal activation pattern in patients with heart failure and left bundle branch block (LBBB\u2010HF).<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> The right ventricular (RV) and left ventricular (LV) activation patterns of 12 patients <jats:styled-content>(mean age 67 <jats:bold>\u00b1<\/jats:bold> 11 years)<\/jats:styled-content> with LBBB\u2010HF and 5 patients <jats:styled-content>(mean age 45 <jats:bold>\u00b1<\/jats:bold> 14)<\/jats:styled-content> with normal hearts were studied during sinus rhythm using a three\u2010dimensional mapping system. The etiology of HF was myocardial infarction <jats:styled-content>(n <jats:bold>=<\/jats:bold> 4)<\/jats:styled-content> or idiopathic dilated cardiomyopathy <jats:styled-content>(n <jats:bold>=<\/jats:bold> 8)<\/jats:styled-content>. In patients with LBBB\u2010HF, endocardial activation usually started before the onset of the surface QRS complex on the RV free wall. Latest RV activation occurred in the basal region, and total RV activation time was longer than in patients with normal hearts. In patients with LBBB\u2010HF, the left septum was activated via slowly conducting LBB or via right\u2010to\u2010left transseptal conduction. In both patients with LBBB\u2010HF and those with normal hearts, latest LV activation occurred either in the posterior or posterolateral\u2010basal region. Conduction velocity was slower in the peri\u2010scar region, in patients with previous myocardial infarct and globally slow, in patients with idiopathic dilated cardiomyopathy.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> The two types of left septal activation observed in patients with LBBB\u2010HF may have consequences for biventricular hemodynamic performance. Conduction slowing along the LV, regionally or globally, suggests a contribution outside the specific conduction system in the ECG pattern of LBBB. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 14, pp. 135\u2010141, February 2003)<\/jats:italic><\/jats:p>","DOI":"10.1046\/j.1540-8167.2003.02421.x","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T09:44:01Z","timestamp":1281951841000},"page":"135-141","source":"Crossref","is-referenced-by-count":137,"title":["Variable Patterns of Septal Activation in Patients with Left Bundle Branch Block and Heart Failure"],"prefix":"10.1111","volume":"14","author":[{"given":"LUZ\u2010MARIA","family":"RODRIGUEZ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARL","family":"TIMMERMANS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ASHISH","family":"NABAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GRAYDON","family":"BEATTY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HEIN J.J.","family":"WELLENS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","unstructured":"RodriguezMI Sodi\u2010PallaresD:The mechanism of complete and incomplete left bundle branch block.Am Heart J1952;43:715\u2010718.","DOI":"10.1016\/0002-8703(52)90099-9"},{"key":"e_1_2_6_3_2","first-page":"337","volume-title":"The Conduction System of the Heart","author":"Van Dam RT","year":"1976"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.61.4.696"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.62.3.621"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.5.914"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.24.2426"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.CIR.98.9.887","article-title":"Simultaneous endocardial mapping in the human LV using a non\u2010contact catheter. 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