{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T14:47:08Z","timestamp":1694530028402},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2003,9,19]],"date-time":"2003-09-19T00:00:00Z","timestamp":1063929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> The interactions between extracellular stimuli and excitation waves propagating in a reentrant loop are a complex function of stimulus parameters, structural properties, membrane state, and timing. Here the goal was a comprehensive understanding of the mechanisms and frequencies of the major interactions between the advancing excitation wave and a single extracellular stimulus, separated from issues of anatomic or geometric complexity.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> A modernized computer model of a thin ring of uniform tissue that included a pair of extracellular stimulus electrodes (anode\/cathode) was used to model one\u2010dimensional cardiac reentry. Questions and results included the following: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#m1\">(1)<\/jats:ext-link> What are the major interactions between a stimulus and the reentrant propagation wave, and are they induced near the cathode or near the anode; and, for each interaction, what are the initiating amplitude range and timing interval? At the cathode, the well\u2010known mechanism of retrograde excitation terminated reentry; changes in timing or amplitude produced double\u2010wave reentry or phase reset. At the anode, termination occurred at different cells depending on stimulus amplitude. (2) Relatively how often did termination occur at the anode? For most stimulus amplitudes, termination occurred more often at the anode than at the cathode, although not always at the same cell. (3) With random timing, what is the probability of terminating reentry? Stimulation for 5 msec terminated reentry with a probability from 0% to approximately 10%, as a function of increasing stimulus amplitude.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> A single extracellular stimulus can initiate major changes in reentrant excitation via multiple mechanisms, even in a simple geometry. Termination of reentry, phase shifts, or double\u2010wave reentry each occurs over well\u2010defined ranges of stimulus amplitude and timing. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 14, pp. ***\u2010***, October 2003)<\/jats:italic><\/jats:p>","DOI":"10.1046\/j.1540-8167.2003.02443.x","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T04:48:13Z","timestamp":1066193293000},"page":"1064-1074","source":"Crossref","is-referenced-by-count":4,"title":["Interactions Between Extracellular Stimuli and Excitation Waves in an Atrial Reentrant Loop"],"prefix":"10.1111","volume":"14","author":[{"given":"CHAD R.","family":"JOHNSON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROGER 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