{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:32:13Z","timestamp":1788582733206,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> Right atrial linear lesions (RALL), either alone or in combination with antiarrhythmic drug therapy, may modify the substrate for maintenance of atrial fibrillation (AF). The aim of this prospective randomized study was to determine whether RALL provides additional benefit to right atrial appendage pacing (RAAP) and\/or interatrial septum pacing (IASP) and drug therapy in patients with symptomatic paroxysmal AF and sinus bradycardia requiring permanent atrial pacing.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> Sixty\u2010four patients (33 men and 31 women, <jats:styled-content>mean age 73 \u00b1 10 years<\/jats:styled-content>) completed the 6\u2010month follow\u2010up. Patients were randomized to either RALL <jats:styled-content>(n = 33)<\/jats:styled-content> or non\u2010right atrial linear lesions (NRALL), and then to either IASP <jats:styled-content>(n = 32)<\/jats:styled-content> or RAAP <jats:styled-content>(n = 32)<\/jats:styled-content>. Fifteen RALL patients were paced at the IAS and 18 at the RAA. Seventeen NRALL patients were paced at the IAS and 14 at the RAA. No statistical difference was observed with regard to the mean atrial tachyarrhythmia (AT) burden between NRALL <jats:styled-content>(84 \u00b1 169 min\/day)<\/jats:styled-content> and RALL patients <jats:styled-content>(202 \u00b1 219 min\/day)<\/jats:styled-content>. Mean AT burden was significantly lower in the IASP group <jats:styled-content>(70 \u00b1 150 min\/day)<\/jats:styled-content> than in RAAP group <jats:styled-content>(219 \u00b1 317 min\/day; P &lt; 0.016)<\/jats:styled-content>. In the RALL group, the mean AT burden was <jats:styled-content>99 \u00b1 180 min\/day<\/jats:styled-content> in the IASP patients and 288 \u00b1 372 min\/day in the RAAP patients <jats:styled-content>(P &lt; 0.046)<\/jats:styled-content>. In the NRALL group, no statistical difference in the mean AT burden was observed between IASP patients <jats:styled-content>(46 \u00b1 117 min\/day)<\/jats:styled-content> and RAAP patients <jats:styled-content>(130 \u00b1 211 min\/day)<\/jats:styled-content>.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> The results of the present study indicate that RALL did not provide any additional therapeutic benefit to combined antiarrhythmic drug therapy and septal or nonseptal atrial pacing in patients with sinus bradycardia and paroxysmal AF. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 14, pp. 733\u2010738, July 2003)<\/jats:italic><\/jats:p>","DOI":"10.1046\/j.1540-8167.2003.02588.x","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T09:40:04Z","timestamp":1281951604000},"page":"733-738","source":"Crossref","is-referenced-by-count":7,"title":["Prevention of Paroxysmal Atrial Fibrillation in Patients with Sinus 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