{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:07:09Z","timestamp":1791014829656,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2003,11,14]],"date-time":"2003-11-14T00:00:00Z","timestamp":1068768000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>\n                    <jats:italic>Introduction:<\/jats:italic>\n                    The combined role of atrial septal lead location and atrial pacing algorithms in the prevention of atrial tachyarrhythmias (AT\/AF), including both atrial fibrillation and flutter, is unknown. We tested the hypothesis that atrial prevention pacing algorithms could decrease AT\/AF frequency in patients with atrial septal leads, bradycardia, and paroxysmal AT\/AF.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods and Results:<\/jats:italic>\n                    A total of 298 patients (age 70 \u00b1 10 years; 61% male) from 35 centers were implanted with a DDDRP pacing system including three AT\/AF prevention pacing algorithms. Lead site was randomized at implant to right atrial septal or nonseptal. Patients were randomized 1 month postimplant to AT\/AF prevention ON or OFF for 3 months and then crossed over for 3 months. Patients logged symptomatic AT\/AF episodes via a manual activator. Prevention efficacy was evaluated based on intention\u2010to\u2010treat in 277 patients (138 septal) with complete follow\u2010up. No changes in device\u2010recorded AT\/AF frequency or burden were observed with algorithms OFF versus ON or between patients randomized to septal versus nonseptal lead location. Analysis of other secondary outcomes revealed that AT\/AF prevention pacing resulted in decreased atrial premature contractions in both the septal (1.9 [0.2\u20138.7] vs 3.3 [0.3\u201310.6]\u00d7 10\n                    <jats:sup>3<\/jats:sup>\n                    \/day; P &lt; 0.01) and nonseptal groups (0.9 [0.2\u20133.3] vs 1.3 [0.3\u20135.5]\u00d7 10\n                    <jats:sup>3<\/jats:sup>\n                    \/day; P &lt; 0.001). Patients with septal leads had fewer symptomatic AT\/AF episodes ON versus OFF (1.4 \u00b1 3.0 vs 2.5 \u00b1 5.2\/month, P = 0.01).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion:<\/jats:italic>\n                    The combination of three atrial prevention pacing algorithms did not decrease device classified atrial tachyarrhythmia frequency or burden during a 3\u2010month cross\u2010over period in bradycardic patients and septal or nonseptal atrial pacing leads. Prevention pacing was associated with decreased frequency of premature atrial contractions and with decreased symptomatic atrial tachyarrhythmia frequency in patients with atrial septal leads.\n                    <jats:italic>(J Cardiovasc Electrophysiol, Vol. 14, pp. 1189\u20101195, November 2003)<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1046\/j.1540-8167.2003.03191.x","type":"journal-article","created":{"date-parts":[[2003,11,14]],"date-time":"2003-11-14T09:39:28Z","timestamp":1068802768000},"page":"1189-1195","source":"Crossref","is-referenced-by-count":136,"title":["Combined Efficacy of Atrial Septal Lead Placement and Atrial Pacing Algorithms for Prevention of Paroxysmal Atrial Tachyarrhythmia"],"prefix":"10.1111","volume":"14","author":[{"given":"LUIGI","family":"PADELETTI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HELMUT","family":"P\u00dcRERFELLNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STUART W.","family":"ADLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THEODORE J.","family":"WALLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARK","family":"HARVEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEWIS","family":"HORVITZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"REECE","family":"HOLBROOK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KITTY","family":"KEMPEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDREW","family":"MUGGLIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DOUGLAS A.","family":"HETTRICK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Worldwide ASPECT Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,11,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.19.2553"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1983.tb05295.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1994.tb03782.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01681-2"},{"key":"e_1_2_6_6_2","first-page":"II\u2010383","article-title":"Dynamic overdrive pacing decreases symptomatic atrial arrhythmia burden in patients with sinus node dysfunction","volume":"104","author":"Carlson MD","year":"2001","journal-title":"Circulation"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03425-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421902"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.01121.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.119373"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1997.tb05431.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00912.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02068-5"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.85.1.48"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2000.tb01752.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00631-8"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.13.1325"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01351-1"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1991"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/01.CIR.103.3.381","article-title":"Critical analysis of dual\u2010chamber implantable cardioverter\u2010defibrillator arrhythmia detection: Results and technical considerations","volume":"23","author":"Wilkoff BL","year":"2001","journal-title":"Circulation"},{"issue":"4","key":"e_1_2_6_21_2","first-page":"853","article-title":"Does consistent atrial pacing algorithm prevent recurrent paroxysmal atrial fibrillation? 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