{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:05:00Z","timestamp":1764493500968},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T00:00:00Z","timestamp":1085356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> The Brugada\u2010type ECG, a terminal r\u2032 wave accompanied by ST segment elevation in the right precordial leads, is not a very rare condition. Most of the cases are men in Japan and elsewhere; however, information about the clinical features of these cases is lacking. The aim of this study was to determine the clinical characteristics of subjects with the Brugada\u2010type ECG, specifically Japanese men.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> We extracted male Brugada\u2010type ECG cases from 3,374 men followed biennially from 1958 through 2001 in Nagasaki, Japan, and compared the clinical characteristics at diagnosis between these cases and four age\u2010matched male controls for each case. A total of 34 cases with the Brugada\u2010type ECG were observed during follow\u2010up. Body mass index (BMI) at diagnosis was significantly lower in Brugada\u2010type ECG cases than in 136 controls (20.2 \u00b1 2.1 kg\/m<jats:sup><jats:bold>2<\/jats:bold><\/jats:sup> vs 21.8 \u00b1 2.8 kg\/m<jats:sup><jats:bold>2<\/jats:bold><\/jats:sup>, P = 0.003). The BMI trend in cases was always lower than that in controls throughout the 8\u2010year observation period (from 4 years before diagnosis to 4 years after diagnosis). Pulse rate at diagnosis was also somewhat lower in Brugada\u2010type ECG cases than in controls (68.9 \u00b1 7.7 beats\/min vs 72.7 \u00b1 11.1 beats\/min, P = 0.038). The significance disappeared after controlling for BMI (P = 0.131) or body weight (P = 0.153).<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> The cases with the Brugada\u2010type ECG had lower BMI than controls, leading to a clue to possible basic mechanisms of the Brugada\u2010type ECG with a focus on this association. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 15, pp. 1\u20105, June 2004)<\/jats:italic><\/jats:p>","DOI":"10.1046\/j.1540-8167.2004.03544.x","type":"journal-article","created":{"date-parts":[[2004,5,28]],"date-time":"2004-05-28T07:24:19Z","timestamp":1085729059000},"page":"653-657","source":"Crossref","is-referenced-by-count":17,"title":["Clinical Characteristics of Subjects with the Brugada\u2010Type Electrocardiogram:"],"prefix":"10.1111","volume":"15","author":[{"given":"KIYOTAKA","family":"MATSUO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASAZUMI","family":"AKAHOSHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EIJI","family":"NAKASHIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHINJI","family":"SETO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATSUSUKE","family":"YANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90253-J"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/32675"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.5.666"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00528-2"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)90032-6"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.5105\/jse.15.223"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00835-3"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01239-6"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01419-X"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01421-8"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.2.161"},{"key":"e_1_2_7_13_2","first-page":"11","volume-title":"Research Plan for Joint ABCC\u2010NIH Adult Health Study in Hiroshima and Nagasaki","author":"Atomic Bomb Casualty Commission","year":"1962"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.1.61"},{"key":"e_1_2_7_15_2","unstructured":"SAS\/STAT User's Guide Release 6.03 Edition. 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