{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:31:58Z","timestamp":1777462318368,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T00:00:00Z","timestamp":1093305600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> Recurrence of atrial fibrillation (AF) may be related to AF\u2010induced electrical remodeling characterized by shortening of the atrial action potential duration (APD) and loss of its rate adaptation. We investigated the effects of pretreatment with oral d,l\u2010sotalol on rate\u2010dependent changes in atrial monophasic action potential (MAP) duration after cardioversion of chronic AF with reference to the efficacy in preventing the arrhythmia recurrence.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> MAPs were recorded from the right atrium at six pacing cycle lengths (CLs) from 300 to 750 ms in 19 chronic AF patients after electrical cardioversion; 9 had been pretreated with oral d,l\u2010sotalol (196 \u00b1 42 mg\/day) for 7 days and 10 were untreated. MAP duration at 90% repolarization (MAPD<jats:sub>90<\/jats:sub>) in 11 control patients increased progressively with increases in CLs from 209 \u00b1 19 ms at CL = 300 ms to 264 \u00b1 28 ms at CL = 750 ms. In AF patients without sotalol, the CL\u2010MAPD relation was shifted downward and flattened at longer CLs; MAPD<jats:sub>90<\/jats:sub> values were 206 \u00b1 11 ms and 227 \u00b1 16 ms at CLs of 300 and 750 ms, respectively. MAPD<jats:sub>90<\/jats:sub> values at CLs \u2265500 ms in AF were significantly shorter than controls. In AF patients with sotalol, the normal CL\u2010MAPD relation was preserved; MAPD<jats:sub>90<\/jats:sub> increased from 226 \u00b1 19 ms to 282 \u00b1 46 ms in the CL range. AF recurred within 2 weeks after cardioversion in 14 of 24 patients pretreated with d,l\u2010sotalol (216 \u00b1 51 mg\/day) despite of continuation of sotalol treatment.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> Sotalol reverses AF\u2010induced decrease in MAPD adaptation to rate in the atria of chronic AF patients, but this effect does not lead to prevention of AF recurrence.<\/jats:p>","DOI":"10.1046\/j.1540-8167.2004.03671.x","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T09:38:48Z","timestamp":1281951528000},"page":"877-884","source":"Crossref","is-referenced-by-count":9,"title":["Sotalol Reverses Remodeled Action Potential in Patients with Chronic Atrial Fibrillation but Does Not Prevent Arrhythmia 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